Arhgef17 (Rho guanine nucleotide exchange factor 17) - Chinchilla Research Resource Database
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Gene: Arhgef17 (Rho guanine nucleotide exchange factor 17) Rattus norvegicus
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Symbol: Arhgef17
Name: Rho guanine nucleotide exchange factor 17
CRRD ID: 1309890
Description: ENCODES a protein that exhibits guanyl-nucleotide exchange factor activity (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); INTERACTS WITH bisphenol A; dibutyl phthalate; valproic acid
Type: protein-coding
Also known as: LOC308862; Rho guanine nucleotide exchange factor (GEF) 17
Orthologs:
Homo sapiens (human) : ARHGEF17 (Rho guanine nucleotide exchange factor 17)  HGNC  Alliance
Mus musculus (house mouse) : Arhgef17 (Rho guanine nucleotide exchange factor (GEF) 17)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Arhgef17 (Rho guanine nucleotide exchange factor 17)
Pan paniscus (bonobo/pygmy chimpanzee) : ARHGEF17 (Rho guanine nucleotide exchange factor 17)
Canis lupus familiaris (dog) : ARHGEF17 (Rho guanine nucleotide exchange factor 17)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Arhgef17 (Rho guanine nucleotide exchange factor 17)
Sus scrofa (pig) : ARHGEF17 (Rho guanine nucleotide exchange factor 17)
Chlorocebus sabaeus (African green monkey) : ARHGEF17 (Rho guanine nucleotide exchange factor 17)
Heterocephalus glaber (naked mole-rat) : Arhgef17 (Rho guanine nucleotide exchange factor 17)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Genome Annotation Status: not in current annotation release
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0 Ensembl1165,911,718 - 165,967,069 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01172,105,535 - 172,164,079 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41158,316,868 - 158,375,737 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11158,399,688 - 158,454,770 (-)NCBI
Celera1153,312,407 - 153,371,361 (-)NCBICelera
Cytogenetic Map1q32NCBI


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

Additional References at PubMed
PMID:12071859  


Genomics

Comparative Map Data
Arhgef17
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0 Ensembl1165,911,718 - 165,967,069 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01172,105,535 - 172,164,079 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41158,316,868 - 158,375,737 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11158,399,688 - 158,454,770 (-)NCBI
Celera1153,312,407 - 153,371,361 (-)NCBICelera
Cytogenetic Map1q32NCBI
ARHGEF17
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1173,308,276 - 73,369,388 (+)EnsemblGRCh38hg38GRCh38
GRCh381173,305,961 - 73,369,388 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371173,019,663 - 73,080,425 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361172,697,317 - 72,757,784 (+)NCBINCBI36hg18NCBI36
Build 341172,697,316 - 72,757,783NCBI
Celera1170,324,908 - 70,385,824 (+)NCBI
Cytogenetic Map11q13.4NCBI
HuRef1169,314,967 - 69,375,701 (+)NCBIHuRef
CHM1_11172,903,220 - 72,964,018 (+)NCBICHM1_1
Arhgef17
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397100,518,953 - 100,581,368 (-)NCBI
GRCm387100,869,746 - 100,932,161 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7100,869,752 - 100,932,107 (-)EnsemblGRCm38mm10GRCm38
MGSCv377108,018,260 - 108,080,675 (-)NCBIGRCm37mm9NCBIm37
MGSCv367100,743,833 - 100,806,248 (-)NCBImm8
Celera7101,220,490 - 101,283,194 (-)NCBICelera
Cytogenetic Map7E2NCBI
Arhgef17
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541418,102,291 - 18,172,477 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541418,100,907 - 18,172,905 (-)NCBIChiLan1.0ChiLan1.0
ARHGEF17
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11171,605,498 - 71,667,001 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1171,605,832 - 71,665,476 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01168,386,143 - 68,445,893 (+)NCBIMhudiblu_PPA_v0panPan3
ARHGEF17
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2124,862,295 - 24,919,667 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12124,859,789 - 24,919,733 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Arhgef17
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049364982,511,516 - 2,570,481 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARHGEF17
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.197,766,701 - 7,826,513 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.298,475,616 - 8,490,736 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ARHGEF17
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl164,552,842 - 64,616,112 (+)Ensembl
ChlSab1.1164,553,134 - 64,613,573 (+)NCBI
Arhgef17
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248173,582,665 - 3,641,258 (-)NCBI

Position Markers
RH133653  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01165,910,472 - 165,910,657NCBIRnor6.0
Rnor_5.01172,107,969 - 172,108,154UniSTSRnor5.0
RGSC_v3.41158,319,426 - 158,319,611UniSTSRGSC3.4
Celera1153,314,841 - 153,315,026UniSTS
Cytogenetic Map1q32UniSTS
RH 3.4 Map11261.39UniSTS
RH134195  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01165,908,104 - 165,908,317NCBIRnor6.0
Rnor_5.01172,105,601 - 172,105,814UniSTSRnor5.0
RGSC_v3.41158,317,058 - 158,317,271UniSTSRGSC3.4
Celera1153,312,473 - 153,312,686UniSTS
Cytogenetic Map1q32UniSTS
RH 3.4 Map11262.2UniSTS
MDB1111  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01165,910,473 - 165,910,609NCBIRnor6.0
Rnor_5.01172,107,970 - 172,108,106UniSTSRnor5.0
RGSC_v3.41158,319,427 - 158,319,563UniSTSRGSC3.4
Celera1153,314,842 - 153,314,978UniSTS
Cytogenetic Map1q32UniSTS
BE119128  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01165,957,536 - 165,957,706NCBIRnor6.0
Rnor_5.01172,154,546 - 172,154,716UniSTSRnor5.0
RGSC_v3.41158,366,204 - 158,366,374UniSTSRGSC3.4
Celera1153,361,820 - 153,361,990UniSTS
Cytogenetic Map1q32UniSTS
RH 3.4 Map11262.1UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:135
Count of miRNA genes:80
Interacting mature miRNAs:85
Transcripts:ENSRNOT00000026047, ENSRNOT00000031423
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 33 14 6 3 6 2 73 34 34 11
Low 3 10 43 35 16 35 8 9 1 1 7 8
Below cutoff

Sequence

Nucleotide Sequences
GenBank Nucleotide CH473956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000089359   ⟹   ENSRNOP00000070400
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1165,911,718 - 165,967,069 (-)Ensembl
RefSeq Acc Id: NM_001107538
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
RGSC_v3.41158,316,868 - 158,375,737 (-)RGD
RefSeq Acc Id: XM_003748932   ⟹   XP_003748980
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_5.01172,105,535 - 172,164,079 (-)NCBI
RefSeq Acc Id: XM_003753340   ⟹   XP_003753388
RefSeq Status:
Type: CODING
Position: No map positions available.
RefSeq Acc Id: XM_006223530   ⟹   XP_006223592
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Celera1153,312,407 - 153,371,361 (-)NCBI
Protein Sequences
GenBank Protein EDM18309 (Get FASTA)   NCBI Sequence Viewer  
  EDM18310 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_003748980   ⟸   XM_003748932
RefSeq Acc Id: XP_003753388   ⟸   XM_003753340
RefSeq Acc Id: XP_006223592   ⟸   XM_006223530
RefSeq Acc Id: ENSRNOP00000070400   ⟸   ENSRNOT00000089359
Protein Domains
DH

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSRNOG00000053502 Ensembl, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000070400 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000089359 UniProtKB/TrEMBL
Gene3D-CATH 1.20.900.10 UniProtKB/TrEMBL
  2.130.10.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
InterPro ARHGEF10/ARHGEF17 UniProtKB/TrEMBL
  ARHGEF17 UniProtKB/TrEMBL
  DBL_dom_sf UniProtKB/TrEMBL
  DH-domain UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/TrEMBL
NCBI Gene 308862 ENTREZGENE
PANTHER PTHR12877 UniProtKB/TrEMBL
  PTHR12877:SF15 UniProtKB/TrEMBL
Pfam RhoGEF UniProtKB/TrEMBL
PhenoGen Arhgef17 PhenoGen
PROSITE DH_2 UniProtKB/TrEMBL
SMART RhoGEF UniProtKB/TrEMBL
Superfamily-SCOP SSF48065 UniProtKB/TrEMBL
  SSF50978 UniProtKB/TrEMBL
UniProt A0A0G2JXT9_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-19 Arhgef17  Rho guanine nucleotide exchange factor 17  Arhgef17  Rho guanine nucleotide exchange factor (GEF) 17  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Arhgef17  Rho guanine nucleotide exchange factor (GEF) 17   Arhgef17_predicted  Rho guanine nucleotide exchange factor (GEF) 17 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Arhgef17_predicted  Rho guanine nucleotide exchange factor (GEF) 17 (predicted)      Symbol and Name status set to approved 70820 APPROVED