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Gene: Crb1 (crumbs cell polarity complex component 1) Rattus norvegicus
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Symbol: Crb1
Name: crumbs cell polarity complex component 1
Description: Predicted to have calcium ion binding activity. Predicted to be involved in several processes, including establishment or maintenance of epithelial cell apical/basal polarity; eye photoreceptor cell development; and heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules. Localizes to the microvillus and photoreceptor inner segment. Human ortholog(s) of this gene implicated in Leber congenital amaurosis; Leber congenital amaurosis 8; cone-rod dystrophy; retinitis pigmentosa; and retinitis pigmentosa 12. Orthologous to human CRB1 (crumbs cell polarity complex component 1); INTERACTS WITH bisphenol A; cannabidiol; 2,3,7,8-tetrachlorodibenzodioxine (ortholog).
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: crumbs 1, cell polarity complex component; crumbs family member 1, photoreceptor morphogenesis associated; crumbs homolog 1; crumbs homolog 1 (Drosophila); LOC304825
Orthologs:
Homo sapiens (human) : CRB1 (crumbs cell polarity complex component 1)  HGNC  Alliance
Mus musculus (house mouse) : Crb1 (crumbs family member 1, photoreceptor morphogenesis associated)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Crb1 (crumbs cell polarity complex component 1)
Pan paniscus (bonobo/pygmy chimpanzee) : CRB1 (crumbs cell polarity complex component 1)
Canis lupus familiaris (dog) : CRB1 (crumbs cell polarity complex component 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Crb1 (crumbs cell polarity complex component 1)
Sus scrofa (pig) : CRB1 (crumbs cell polarity complex component 1)
more info ...
Allele / Splice: Crb1m1  
Genetic Models: BN-Crb1m1
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01356,270,519 - 56,462,893 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01361,292,273 - 61,369,526 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01361,413,282 - 61,480,872 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41352,558,317 - 52,725,099 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11352,572,656 - 52,715,591 (-)NCBI
Celera1351,073,846 - 51,253,703 (-)NCBICelera
Cytogenetic Map13q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Crb1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1309947
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.