Gene: Mthfr (methylenetetrahydrofolate reductase) Rattus norvegicus
Symbol: Mthfr
Name: methylenetetrahydrofolate reductase
Description: Exhibits NADP binding activity, flavin adenine dinucleotide binding activity, and methylenetetrahydrofolate reductase (NAD(P)H) activity; involved in several processes, including S-adenosylmethionine metabolic process, carboxylic acid metabolic process, and response to vitamin; localizes to the cytosol and synapse; biomarker of hyperthyroidism, hypothyroidism, and liver benign neoplasm; orthologous to human MTHFR (methylenetetrahydrofolate reductase); PARTICIPATES IN altered folate cycle metabolic pathway; altered folate mediated one-carbon metabolic pathway; folate cycle metabolic pathway; INTERACTS WITH 2-acetamidofluorene; 3-chloropropane-1,2-diol; ammonium chloride.
Type: protein-coding
RefSeq Status: MODEL
Also known as: 5,10-methylenetetrahydrofolate reductase; 5,10-methylenetetrahydrofolate reductase (NADPH); LOC362657; methylenetetrahydrofolate reductase (NAD(P)H)
Homo sapiens (human) : MTHFR (methylenetetrahydrofolate reductase)  HGNC  Alliance
Mus musculus (house mouse) : Mthfr (methylenetetrahydrofolate reductase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mthfr (methylenetetrahydrofolate reductase)
Pan paniscus (bonobo/pygmy chimpanzee) : MTHFR (methylenetetrahydrofolate reductase)
Canis lupus familiaris (dog) : MTHFR (methylenetetrahydrofolate reductase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mthfr (methylenetetrahydrofolate reductase)
Sus scrofa (pig) : MTHFR (methylenetetrahydrofolate reductase)
more info ...
Allele / Splice: Mthfrem1Mcwi  
Genetic Models: SS-Mthfrem1Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.05164,844,642 - 164,864,360 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05168,502,556 - 168,522,350 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45165,112,850 - 165,126,885 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15165,123,406 - 165,137,073 (+)NCBI
Celera5156,747,024 - 156,766,742 (+)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Mthfr
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1309952
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.