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Gene: Smurf2 (SMAD specific E3 ubiquitin protein ligase 2) Rattus norvegicus
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Symbol: Smurf2
Name: SMAD specific E3 ubiquitin protein ligase 2
Description: Exhibits SMAD binding activity and transforming growth factor beta receptor binding activity. Predicted to be involved in several processes, including negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; positive regulation of trophoblast cell migration; and ubiquitin-dependent protein catabolic process. Predicted to localize to the cytoplasm; nuclear speck; and ubiquitin ligase complex. Orthologous to human SMURF2 (SMAD specific E3 ubiquitin protein ligase 2); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; endocytosis pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: E3 ubiquitin-protein ligase SMURF2; LOC303614; RGD1310067; similar to E3 ubiquitin ligase SMURF2
Orthologs:
Homo sapiens (human) : SMURF2 (SMAD specific E3 ubiquitin protein ligase 2)  HGNC  Alliance
Mus musculus (house mouse) : Smurf2 (SMAD specific E3 ubiquitin protein ligase 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Smurf2 (SMAD specific E3 ubiquitin protein ligase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : SMURF2 (SMAD specific E3 ubiquitin protein ligase 2)
Canis lupus familiaris (dog) : SMURF2 (SMAD specific E3 ubiquitin protein ligase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Smurf2 (SMAD specific E3 ubiquitin protein ligase 2)
Sus scrofa (pig) : SMURF2 (SMAD specific E3 ubiquitin protein ligase 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01095,018,050 - 95,118,107 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01094,763,750 - 94,863,160 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41096,170,590 - 96,269,365 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11096,187,581 - 96,283,629 (-)NCBI
Celera1090,428,224 - 90,528,224 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
 
More on Smurf2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1310067
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.