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Gene: Uros (uroporphyrinogen III synthase) Rattus norvegicus
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Symbol: Uros
Name: uroporphyrinogen III synthase
Description: Exhibits cofactor binding activity. Contributes to uroporphyrinogen-III synthase activity. Involved in several processes, including cellular response to amine stimulus; response to platinum ion; and uroporphyrinogen III biosynthetic process. Localizes to the cytosol. Human ortholog(s) of this gene implicated in cutaneous porphyria. Orthologous to human UROS (uroporphyrinogen III synthase); PARTICIPATES IN acute intermittent porphyria pathway; erythropoietic porphyria pathway; heme biosynthetic pathway; INTERACTS WITH (+)-schisandrin B; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: LOC309070; urogen III synthase; uroporphyrinogen III co-synthase; uroporphyrinogen-III synthase
Orthologs:
Homo sapiens (human) : UROS (uroporphyrinogen III synthase)  HGNC  Alliance
Mus musculus (house mouse) : Uros (uroporphyrinogen III synthase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Uros (uroporphyrinogen III synthase)
Pan paniscus (bonobo/pygmy chimpanzee) : UROS (uroporphyrinogen III synthase)
Canis lupus familiaris (dog) : UROS (uroporphyrinogen III synthase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Uros (uroporphyrinogen III synthase)
Sus scrofa (pig) : UROS (uroporphyrinogen III synthase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01205,755,766 - 205,778,170 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01212,704,834 - 212,727,235 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41193,184,946 - 193,205,475 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11193,334,828 - 193,355,356 (-)NCBI
Celera1186,229,349 - 186,249,866 (-)NCBICelera
Cytogenetic Map1q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Uros
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1310396
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.