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Gene: Sirt4 (sirtuin 4) Rattus norvegicus
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Symbol: Sirt4
Name: sirtuin 4
Description: Predicted to have NAD+ ADP-ribosyltransferase activity; NAD-dependent protein deacetylase activity; and hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds. Involved in cellular response to hypoxia; negative regulation of cardiac muscle cell apoptotic process; and negative regulation of protein processing involved in protein targeting to mitochondrion. Localizes to the mitochondrion. Biomarker of nonalcoholic fatty liver disease. Orthologous to human SIRT4 (sirtuin 4); PARTICIPATES IN histone modification pathway; Sirtuin mediated pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol 3-benzoate; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: LOC304539; NAD-dependent ADP-ribosyltransferase sirtuin-4; NAD-dependent protein deacetylase sirtuin-4; NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; sirtuin (silent mating type information regulation 2 homolog) 4 (S. cerevisiae); sirtuin 4 (silent mating type information regulation 2 homolog) 4 (S. cerevisiae)
Orthologs:
Homo sapiens (human) : SIRT4 (sirtuin 4)  HGNC  Alliance
Mus musculus (house mouse) : Sirt4 (sirtuin 4)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sirt4 (sirtuin 4)
Pan paniscus (bonobo/pygmy chimpanzee) : SIRT4 (sirtuin 4)
Canis lupus familiaris (dog) : SIRT4 (sirtuin 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sirt4 (sirtuin 4)
Sus scrofa (pig) : SIRT4 (sirtuin 4)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01246,862,358 - 46,876,593 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01248,665,591 - 48,673,711 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41242,394,536 - 42,402,714 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11242,241,793 - 42,268,052 (+)NCBI
Celera1242,754,699 - 42,762,759 (+)NCBICelera
Cytogenetic Map12q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on Sirt4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1310413
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.