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Gene: Plekhg4 (pleckstrin homology and RhoGEF domain containing G4) Rattus norvegicus
Symbol: Plekhg4
Name: pleckstrin homology and RhoGEF domain containing G4
Description: Predicted to have Rho guanyl-nucleotide exchange factor activity. Predicted to be involved in activation of GTPase activity. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 4. Orthologous to human PLEKHG4 (pleckstrin homology and RhoGEF domain containing G4); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; Rho/Rac/Cdc42 mediated signaling pathway; INTERACTS WITH bisphenol A; copper atom; copper(0).
Type: protein-coding
RefSeq Status: MODEL
Also known as: LOC307796; pleckstrin homology domain containing, family G (with RhoGef domain) member 4; puratrophin-1; RGD1310790; similar to FLJ00068 protein
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01937,327,395 - 37,345,047 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01948,195,669 - 48,210,367 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41935,190,188 - 35,197,607 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11935,190,890 - 35,202,169 (+)NCBI
Celera1932,677,414 - 32,695,066 (+)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Plekhg4
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1310790
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.