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Gene: Tardbp (TAR DNA binding protein) Rattus norvegicus
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Symbol: Tardbp
Name: TAR DNA binding protein
Description: Exhibits RNA binding activity. Involved in positive regulation of insulin secretion and response to endoplasmic reticulum stress. Localizes to the cytoplasm and nucleus. Human ortholog(s) of this gene implicated in Parkinson's disease; amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 10; and motor neuron disease. Orthologous to human TARDBP (TAR DNA binding protein); INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: LOC298648; TAR DNA-binding protein 43; Tdp-43
Orthologs:
Homo sapiens (human) : TARDBP (TAR DNA binding protein)  HGNC  Alliance
Mus musculus (house mouse) : Tardbp (TAR DNA binding protein)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tardbp (TAR DNA binding protein)
Pan paniscus (bonobo/pygmy chimpanzee) : TARDBP (TAR DNA binding protein)
Canis lupus familiaris (dog) : TARDBP (TAR DNA binding protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tardbp (TAR DNA binding protein)
Sus scrofa (pig) : TARDBP (TAR DNA binding protein)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.05165,432,089 - 165,442,232 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05169,088,684 - 169,099,216 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45165,698,665 - 165,709,531 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15165,708,851 - 165,719,708 (-)NCBI
Celera5157,327,910 - 157,337,955 (-)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Tardbp
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1310906
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.