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Gene: Sos1 (SOS Ras/Rac guanine nucleotide exchange factor 1) Rattus norvegicus
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Symbol: Sos1
Name: SOS Ras/Rac guanine nucleotide exchange factor 1
Description: Exhibits SH3 domain binding activity. Involved in Ras protein signal transduction; neurotrophin TRK receptor signaling pathway; and positive regulation of signal transduction. Localizes to neuronal cell body; plasma membrane; and postsynaptic density. Human ortholog(s) of this gene implicated in Noonan syndrome; Noonan syndrome 4; and gingival fibromatosis. Orthologous to human SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; insulin signaling pathway; nerve growth factor signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: LOC313845; Son of sevenless homolog 1; Son of sevenless homolog 1 (Drosophila)
Orthologs:
Homo sapiens (human) : SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1)  HGNC  Alliance
Mus musculus (house mouse) : Sos1 (SOS Ras/Rac guanine nucleotide exchange factor 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sos1 (SOS Ras/Rac guanine nucleotide exchange factor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1)
Canis lupus familiaris (dog) : SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sos1 (SOS Ras/Rac guanine nucleotide exchange factor 1)
Sus scrofa (pig) : SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1)
Chlorocebus sabaeus (African green monkey) : SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1)
Heterocephalus glaber (naked mole-rat) : Sos1 (SOS Ras/Rac guanine nucleotide exchange factor 1)
more info ...
Is Marker For: Strains:   NP.P-(D4Rat119-D4Rat55)/Iusm  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.063,105,443 - 3,182,977 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl63,104,861 - 3,182,996 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.063,082,456 - 3,159,445 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.463,308,778 - 3,390,661 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.163,310,822 - 3,394,313 (-)NCBI
Celera614,210,655 - 14,287,471 (+)NCBICelera
Cytogenetic Map6q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on Sos1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1310949
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2020-07-28
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.