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Gene: Nlrp1a (NLR family, pyrin domain containing 1A) Rattus norvegicus
Symbol: Nlrp1a
Name: NLR family, pyrin domain containing 1A
Description: Exhibits scaffold protein binding activity. Predicted to be involved in several processes, including NLRP1 inflammasome complex assembly; activation of cysteine-type endopeptidase activity involved in apoptotic process; and positive regulation of interleukin-1 beta secretion. Localizes to the neuronal cell body and protein-containing complex. Human ortholog(s) of this gene implicated in vitiligo. Orthologous to human NLRP1 (NLR family pyrin domain containing 1); PARTICIPATES IN interleukin-1 signaling pathway; NOD-like receptor signaling pathway; INTERACTS WITH bisphenol A; diazinon; diclofenac.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: LOC360557; NACHT, leucine rich repeat and PYD containing 1; NACHT, LRR and PYD domains-containing protein 1; Nalp1; NLR family protein 1; NLR family, pyrin domain containing 1; Nlrp1; resistant anthrax lethal toxin
Homo sapiens (human) : NLRP1 (NLR family pyrin domain containing 1)  HGNC  Alliance
Mus musculus (house mouse) : Nlrp1a (NLR family, pyrin domain containing 1A)  MGI  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : NLRP1 (NLR family pyrin domain containing 1)
Canis lupus familiaris (dog) : NLRP1 (NLR family pyrin domain containing 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nlrp1 (NLR family pyrin domain containing 1)
Sus scrofa (pig) : NLRP1 (NLR family pyrin domain containing 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01057,692,474 - 57,747,608 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01057,437,815 - 57,492,207 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41057,963,708 - 58,007,925 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11057,960,835 - 58,122,088 (-)NCBI
Celera1054,924,259 - 54,970,955 (-)NCBICelera
Cytogenetic Map10q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Nlrp1a
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1310963
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.