Gene: Mecom (MDS1 and EVI1 complex locus) Rattus norvegicus
Symbol: Mecom
Name: MDS1 and EVI1 complex locus
Description: Predicted to have DNA-binding transcription factor activity, RNA polymerase II regulatory region sequence-specific DNA binding activity, and protein homodimerization activity; predicted to be involved in several processes, including animal organ development, appendage morphogenesis, and negative regulation of cellular metabolic process; predicted to colocalize with the histone deacetylase complex; orthologous to human MECOM (MDS1 and EVI1 complex locus); PARTICIPATES IN chronic myeloid leukemia pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH all-trans-retinoic acid; bisphenol A; cannabidiol.
Type: protein-coding
Also known as: ecotropic viral integration site 1; Evi1; LOC294924; Mds1; MDS1 and EVI1 complex locus protein EVI1; myelodysplasia syndrome 1 homolog
Homo sapiens (human) : MECOM (MDS1 and EVI1 complex locus)  HGNC  Alliance
Mus musculus (house mouse) : Mecom (MDS1 and EVI1 complex locus)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mecom (MDS1 and EVI1 complex locus)
Pan paniscus (bonobo/pygmy chimpanzee) : MECOM (MDS1 and EVI1 complex locus)
Canis lupus familiaris (dog) : MECOM (MDS1 and EVI1 complex locus)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mecom (MDS1 and EVI1 complex locus)
Sus scrofa (pig) : MECOM (MDS1 and EVI1 complex locus)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.02117,396,084 - 117,993,604 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02137,080,581 - 137,665,758 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42114,814,409 - 114,882,676 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12114,759,366 - 114,831,177 (-)NCBI
Celera2108,052,044 - 108,638,470 (+)NCBICelera
Cytogenetic Map2q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Mecom
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1310997
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.