Gene: Aire (autoimmune regulator) Rattus norvegicus
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Symbol:
Aire
Name:
autoimmune regulator
Description:
Predicted to have several functions, including RNA polymerase II regulatory region sequence-specific DNA binding activity; identical protein binding activity; and zinc ion binding activity. Predicted to be involved in several processes, including immune system development; positive regulation of transcription by RNA polymerase II; and regulation of thymocyte migration. Predicted to localize to the cytoplasm and nuclear body. Human ortholog(s) of this gene implicated in autoimmune polyendocrine syndrome and autoimmune polyendocrine syndrome type 1. Orthologous to human AIRE (autoimmune regulator); PARTICIPATES IN primary immunodeficiency pathway; ubiquitin/proteasome degradation pathway; INTERACTS WITH acrylamide; bisphenol A; cadmium dichloride.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy); LOC294328
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
AIRE (autoimmune regulator) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):
Aire (autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Aire (autoimmune regulator) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
AIRE (autoimmune regulator) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
AIRE (autoimmune regulator) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Aire (autoimmune regulator) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
AIRE (autoimmune regulator) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
AIRE (autoimmune regulator)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Mus musculus (house mouse):
Aire (autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy))
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
aire (autoimmune regulator)
Alliance
DIOPT (Ensembl Compara, OMA, OrthoFinder, PANTHER, TreeFam)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 20 11,365,630 - 11,380,636 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 20 11,365,697 - 11,380,631 (+) Ensembl Rnor_5.0 20 13,535,776 - 13,550,486 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 20 10,980,031 - 10,996,102 (+) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 20 10,980,315 - 10,996,140 (+) NCBI Celera 20 12,141,888 - 12,156,863 (+) NCBI Celera Cytogenetic Map 20 p12 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
autistic disorder ISO RGD:1322440 8554872 ClinVar Annotator: match by term: Autistic disorder of childhood onset ClinVar PMID:21681106 , PMID:30208311 autoimmune polyendocrine syndrome type 1 ISO RGD:1322440 8554872 ClinVar Annotator: match by term: Polyglandular autoimmune syndrome, type 1 ClinVar autoimmune polyendocrine syndrome type 1 ISO RGD:1322440 8554872 ClinVar Annotator: match by term: Polyglandular autoimmune syndrome, type 1 ClinVar PMID:11524731 more ... autoimmune polyendocrine syndrome type 1 ISO RGD:1322440 8554872 ClinVar Annotator: match by term: Polyglandular autoimmune syndrome, type 1 ClinVar PMID:25064028 , PMID:28492532 autoimmune polyendocrine syndrome type 1 ISO RGD:1322440 8554872 ClinVar Annotator: match by term: Polyglandular autoimmune syndrome, type 1 ClinVar PMID:18682433 more ... autoimmune polyendocrine syndrome type 1 ISO RGD:1322440 8554872 ClinVar Annotator: match by term: Polyglandular autoimmune syndrome, type 1 ClinVar PMID:10946904 more ... autoimmune polyendocrine syndrome type 1 ISO RGD:1322440 8554872 ClinVar Annotator: match by term: Polyglandular autoimmune syndrome, type 1 ClinVar PMID:11524731 more ... autoimmune polyendocrine syndrome type 1 ISO RGD:1322440 8554872 ClinVar Annotator: match by term: Polyglandular autoimmune syndrome, type 1 ClinVar PMID:17101293 more ... autoimmune polyendocrine syndrome type 1 ISO RGD:1322440 8554872 ClinVar Annotator: match by term: Polyglandular autoimmune syndrome, type 1 ClinVar PMID:10677297 more ... autoimmune polyendocrine syndrome type 1 ISO RGD:1322440 8554872 ClinVar Annotator: match by term: Polyglandular autoimmune syndrome, type 1 ClinVar PMID:11524731 more ... autoimmune polyendocrine syndrome type 1 ISO RGD:1322440 8554872 ClinVar Annotator: match by term: Polyglandular autoimmune syndrome, type 1 ClinVar PMID:25741868 more ... autoimmune polyendocrine syndrome type 1 ISO RGD:1322440 8554872 ClinVar Annotator: match by term: Polyglandular autoimmune syndrome, type 1 ClinVar PMID:10677297 more ... autoimmune polyendocrine syndrome type 1 ISO RGD:1322440 8554872 ClinVar Annotator: match by term: Polyglandular autoimmune syndrome, type 1 ClinVar PMID:17118990 more ... autoimmune polyendocrine syndrome type 1 ISO RGD:1322440 8554872 ClinVar Annotator: match by term: Polyglandular autoimmune syndrome, type 1 ClinVar PMID:26467025 more ... autoimmune polyendocrine syndrome type 1 ISO RGD:1322440 8554872 ClinVar Annotator: match by term: Polyglandular autoimmune syndrome, type 1 ClinVar PMID:11524733 more ... autoimmune polyendocrine syndrome type 1 ISO RGD:1322440 8554872 ClinVar Annotator: match by term: Polyglandular autoimmune syndrome, type 1 ClinVar PMID:10677297 more ... autoimmune polyendocrine syndrome type 1 ISO RGD:1322440 8554872 ClinVar Annotator: match by term: Polyglandular autoimmune syndrome, type 1 ClinVar PMID:11836330 more ... autoimmune polyendocrine syndrome type 1 ISO RGD:1322440 8554872 ClinVar Annotator: match by term: Polyglandular autoimmune syndrome, type 1 ClinVar PMID:25741868 , PMID:26467025 autoimmune polyendocrine syndrome type 1 ISO RGD:1322440 8554872 ClinVar Annotator: match by term: Polyglandular autoimmune syndrome, type 1 ClinVar PMID:18414213 more ... autoimmune polyendocrine syndrome type 1 ISO RGD:1322440 8554872 ClinVar Annotator: match by term: Polyglandular autoimmune syndrome, type 1 ClinVar PMID:11836330 , PMID:16965330 autoimmune polyendocrine syndrome type 1 ISO RGD:1322440 8554872 ClinVar Annotator: match by term: Polyglandular autoimmune syndrome, type 1 ClinVar PMID:16965330 , PMID:28567288 autoimmune polyendocrine syndrome type 1 ISO RGD:1322440 8554872 ClinVar Annotator: match by term: Polyglandular autoimmune syndrome, type 1 ClinVar PMID:12843157 , PMID:26084028 autoimmune polyendocrine syndrome type 1 ISO RGD:1322440 8554872 ClinVar Annotator: match by term: Polyglandular autoimmune syndrome, type 1 ClinVar PMID:27588307 autoimmune polyendocrine syndrome type 1 ISO RGD:1322440 8554872 ClinVar Annotator: match by term: Polyglandular autoimmune syndrome, type 1 ClinVar PMID:18426830 more ... autoimmune polyendocrine syndrome type 1 ISO RGD:1322440 8554872 ClinVar Annotator: match by term: Polyglandular autoimmune syndrome, type 1 ClinVar PMID:26114819 , PMID:9888391 autoimmune polyendocrine syndrome type 1 ISO RGD:1322440 8554872 ClinVar Annotator: match by term: Polyglandular autoimmune syndrome, type 1 ClinVar PMID:20140861 autoimmune polyendocrine syndrome type 1 ISO RGD:1322440 8554872 ClinVar Annotator: match by term: Polyglandular autoimmune syndrome, type 1 ClinVar PMID:17118990 more ... autoimmune polyendocrine syndrome type 1 ISO RGD:1322440 8554872 ClinVar Annotator: match by term: Polyglandular autoimmune syndrome, type 1 ClinVar PMID:19758376 autoimmune polyendocrine syndrome type 1 ISO RGD:1322440 8554872 ClinVar Annotator: match by term: Polyglandular autoimmune syndrome, type 1 ClinVar PMID:12625412 autoimmune polyendocrine syndrome type 1 ISO RGD:1322440 8554872 ClinVar Annotator: match by term: Polyglandular autoimmune syndrome, type 1 ClinVar PMID:18682433 more ... autoimmune polyendocrine syndrome type 1 ISO RGD:1322440 8554872 ClinVar Annotator: match by term: Polyglandular autoimmune syndrome, type 1 ClinVar PMID:26114819 autoimmune polyendocrine syndrome type 1 ISO RGD:1322440 8554872 ClinVar Annotator: match by term: Polyglandular autoimmune syndrome, type 1 ClinVar PMID:22162465 autoimmune polyendocrine syndrome type 1 ISO RGD:1322440 8554872 ClinVar Annotator: match by term: Polyglandular autoimmune syndrome, type 1 ClinVar PMID:10677297 more ... autoimmune polyendocrine syndrome type 1 ISO RGD:1322440 8554872 ClinVar Annotator: match by term: Polyglandular autoimmune syndrome, type 1 ClinVar PMID:18682433 , PMID:28492532 autoimmune polyendocrine syndrome type 1 ISO RGD:1322440 8554872 ClinVar Annotator: match by term: Polyglandular autoimmune syndrome, type 1 ClinVar PMID:26467025 , PMID:28492532 autoimmune polyendocrine syndrome type 1 ISO RGD:1322440 8554872 ClinVar Annotator: match by term: Polyglandular autoimmune syndrome, type 1 ClinVar PMID:28492532 , PMID:9717837 autoimmune polyendocrine syndrome type 1 ISO RGD:1322440 8554872 ClinVar Annotator: match by term: Polyglandular autoimmune syndrome, type 1 ClinVar PMID:11836330 more ... autoimmune polyendocrine syndrome type 1 ISO RGD:1322440 8554872 ClinVar Annotator: match by term: Polyglandular autoimmune syndrome, type 1 ClinVar PMID:11524731 more ... autoimmune polyendocrine syndrome type 1 ISO RGD:1322440 8554872 ClinVar Annotator: match by term: Polyglandular autoimmune syndrome, type 1 ClinVar PMID:11524731 autoimmune polyendocrine syndrome type 1 ISO RGD:1322440 8554872 ClinVar Annotator: match by term: Polyglandular autoimmune syndrome, type 1 ClinVar PMID:12050215 more ... autoimmune polyendocrine syndrome type 1 ISO RGD:1322440 8554872 ClinVar Annotator: match by term: Polyglandular autoimmune syndrome, type 1 ClinVar PMID:25741868 , PMID:28492532 autoimmune polyendocrine syndrome type 1 ISO RGD:1322440 8554872 ClinVar Annotator: match by term: Polyglandular autoimmune syndrome, type 1 ClinVar PMID:12050215 more ... autoimmune polyendocrine syndrome type 1 ISO RGD:1322440 8554872 ClinVar Annotator: match by term: Polyglandular autoimmune syndrome, type 1 ClinVar PMID:28492532 autoimmune polyendocrine syndrome type 1 ISO RGD:1322440 8554872 ClinVar Annotator: match by term: Polyglandular autoimmune syndrome, type 1 ClinVar PMID:10677297 autoimmune polyendocrine syndrome type 1 ISO RGD:1322440 8554872 ClinVar Annotator: match by term: Polyglandular autoimmune syndrome, type 1 ClinVar PMID:10677297 more ... autoimmune polyendocrine syndrome type 1 ISO RGD:1322440 8554872 ClinVar Annotator: match by term: Polyglandular autoimmune syndrome, type 1 ClinVar PMID:10677297 more ... autoimmune polyendocrine syndrome type 1 ISO RGD:1322440 8554872 ClinVar Annotator: match by term: Polyglandular autoimmune syndrome, type 1 ClinVar PMID:25741868 autoimmune polyendocrine syndrome type 1 ISO RGD:1322440 8554872 ClinVar Annotator: match by term: AUTOIMMUNE POLYENDOCRINOPATHY SYNDROME, TYPE I ClinVar PMID:9398839 autoimmune polyendocrine syndrome type 1 ISO RGD:1322440 8554872 ClinVar Annotator: match by term: AUTOIMMUNE POLYENDOCRINOPATHY SYNDROME, TYPE I ClinVar PMID:19807739 autoimmune polyendocrine syndrome type 1 ISO RGD:1322440 8554872 ClinVar Annotator: match by term: AUTOIMMUNE POLYENDOCRINOPATHY SYNDROME, TYPE I ClinVar PMID:19758376 , PMID:9888391 autoimmune polyendocrine syndrome type 1 ISO RGD:1322440 8554872 ClinVar Annotator: match by synonym: AUTOIMMUNE POLYENDOCRINOPATHY SYNDROME, TYPE I, AUTOSOMAL DOMINANT ClinVar PMID:11600535 more ... autoimmune polyendocrine syndrome type 1 ISO RGD:1322440 8554872 ClinVar Annotator: match by term: AUTOIMMUNE POLYENDOCRINOPATHY SYNDROME, TYPE I ClinVar PMID:10946904 autoimmune polyendocrine syndrome type 1 ISO RGD:1322440 8554872 ClinVar Annotator: match by synonym: AUTOIMMUNE POLYENDOCRINOPATHY SYNDROME, TYPE I, WITH REVERSIBLE METAPHYSEAL DYSPLASIA ClinVar PMID:14557425 autoimmune polyendocrine syndrome type 1 ISO RGD:1322440 8554872 ClinVar Annotator: match by term: Polyglandular autoimmune syndrome, type 1 ClinVar PMID:18414213 , PMID:28492532 autoimmune polyendocrine syndrome type 1 ISO RGD:1322440 8554872 ClinVar Annotator: match by OMIM:240300 ClinVar PMID:16166780 more ... melanoma ISO RGD:1322440 8554872 ClinVar Annotator: match by term: Malignant melanoma ClinVar Neurodevelopmental Disorders ISO RGD:1322440 8554872 ClinVar Annotator: match by term: Neurodevelopmental disorder ClinVar PMID:25741868
Gene-Chemical Interaction Annotations
