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Gene: Vcl (vinculin) Rattus norvegicus
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Symbol: Vcl
Name: vinculin
Description: Exhibits Rho GTPase binding activity. Predicted to be involved in several processes, including axon extension; lamellipodium assembly; and protein localization to cell surface. Localizes to the Z disc; intercalated disc; and sarcolemma. Colocalizes with the actin filament; focal adhesion; and stress fiber. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; dilated cardiomyopathy 1W; hypertrophic cardiomyopathy; and hypertrophic cardiomyopathy 15. Orthologous to human VCL (vinculin); PARTICIPATES IN E-cadherin signaling pathway; vascular endothelial growth factor signaling pathway; Entamoebiasis pathway; INTERACTS WITH 1,3-dinitrobenzene; 2,6-dinitrotoluene; 2-methoxyethanol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: LOC305679; metavinculin
Orthologs:
Homo sapiens (human) : VCL (vinculin)  HGNC  Alliance
Mus musculus (house mouse) : Vcl (vinculin)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Vcl (vinculin)
Pan paniscus (bonobo/pygmy chimpanzee) : VCL (vinculin)
Canis lupus familiaris (dog) : VCL (vinculin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Vcl (vinculin)
Sus scrofa (pig) : VCL (vinculin)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0153,455,211 - 3,544,738 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0153,433,521 - 3,522,441 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4153,478,214 - 3,576,911 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1153,480,194 - 3,654,123 (-)NCBI
Celera151,235,777 - 1,325,408 (+)NCBICelera
Cytogenetic Map15p16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Vcl
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1311217
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.