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Gene: Slc12a6 (solute carrier family 12, member 6) Rattus norvegicus
Symbol: Slc12a6
Name: solute carrier family 12, member 6
Description: Predicted to have ammonium transmembrane transporter activity; potassium:chloride symporter activity; and protein kinase binding activity. Predicted to be involved in several processes, including cellular hypotonic salinity response; inorganic ion homeostasis; and inorganic ion transmembrane transport. Predicted to localize to axon and basolateral plasma membrane. Human ortholog(s) of this gene implicated in agenesis of the corpus callosum with peripheral neuropathy. Orthologous to human SLC12A6 (solute carrier family 12 member 6); PARTICIPATES IN amiloride pharmacodynamics pathway; bendroflumethiazide pharmacodynamics pathway; bumetanide pharmacodynamics pathway; INTERACTS WITH 1,2-dimethylhydrazine; 1,3-dinitrobenzene; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
Also known as: furosemide-sensitive KCl cotransporter 3; Kcc3; LOC362189; LOC691209; similar to Solute carrier family 12 member 6 (Electroneutral potassium-chloride cotransporter 3) (K-Cl cotransporter 3); solute carrier family 12 member 6
Homo sapiens (human) : SLC12A6 (solute carrier family 12 member 6)  HGNC  Alliance
Mus musculus (house mouse) : Slc12a6 (solute carrier family 12, member 6)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Slc12a6 (solute carrier family 12 member 6)
Pan paniscus (bonobo/pygmy chimpanzee) : SLC12A6 (solute carrier family 12 member 6)
Canis lupus familiaris (dog) : SLC12A6 (solute carrier family 12 member 6)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Slc12a6 (solute carrier family 12 member 6)
Sus scrofa (pig) : SLC12A6 (solute carrier family 12 member 6)
Chlorocebus sabaeus (African green monkey) : SLC12A6 (solute carrier family 12 member 6)
Heterocephalus glaber (naked mole-rat) : Slc12a6 (solute carrier family 12 member 6)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.03103,752,213 - 103,852,686 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3103,753,238 - 103,852,686 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03110,347,112 - 110,446,527 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4398,110,547 - 98,212,242 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1398,005,593 - 98,106,019 (+)NCBI
Celera398,058,005 - 98,155,735 (+)NCBICelera
Cytogenetic Map3q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Slc12a6
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1311335
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.