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Gene: Aldh18a1 (aldehyde dehydrogenase 18 family, member A1) Rattus norvegicus
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Symbol: Aldh18a1
Name: aldehyde dehydrogenase 18 family, member A1
Description: Predicted to have glutamate 5-kinase activity; glutamate-5-semialdehyde dehydrogenase activity; and identical protein binding activity. Involved in response to temperature stimulus. Localizes to mitochondrial membrane. Human ortholog(s) of this gene implicated in cataract; cutis laxa (multiple); enterocele; and hereditary spastic paraplegia (multiple). Orthologous to human ALDH18A1 (aldehyde dehydrogenase 18 family member A1); PARTICIPATES IN arginine and proline metabolic pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: delta-1-pyrroline-5-carboxylate synthase; LOC361755; Pycs; pyrroline-5-carboxylate synthetase (glutamate gamma-semialdehyde synthetase)
Orthologs:
Homo sapiens (human) : ALDH18A1 (aldehyde dehydrogenase 18 family member A1)  HGNC  Alliance
Mus musculus (house mouse) : Aldh18a1 (aldehyde dehydrogenase 18 family, member A1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Aldh18a1 (aldehyde dehydrogenase 18 family member A1)
Pan paniscus (bonobo/pygmy chimpanzee) : ALDH18A1 (aldehyde dehydrogenase 18 family member A1)
Canis lupus familiaris (dog) : ALDH18A1 (aldehyde dehydrogenase 18 family member A1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101975532 (delta-1-pyrroline-5-carboxylate synthase)
Sus scrofa (pig) : ALDH18A1 (aldehyde dehydrogenase 18 family member A1)
Chlorocebus sabaeus (African green monkey) : ALDH18A1 (aldehyde dehydrogenase 18 family member A1)
Heterocephalus glaber (naked mole-rat) : Aldh18a1 (aldehyde dehydrogenase 18 family member A1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01259,641,673 - 259,674,521 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1259,641,676 - 259,674,425 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1259,057,402 - 259,089,642 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01266,505,493 - 266,537,820 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01267,085,392 - 267,117,725 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41245,685,979 - 245,718,198 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11245,796,065 - 245,825,127 (-)NCBI
Celera1235,221,086 - 235,253,280 (-)NCBICelera
Cytogenetic Map1q54NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on Aldh18a1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1311431
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.