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Gene: Spry2 (sprouty RTK signaling antagonist 2) Rattus norvegicus
Symbol: Spry2
Name: sprouty RTK signaling antagonist 2
Description: Predicted to have protein kinase binding activity and protein serine/threonine kinase activator activity. Predicted to be involved in several processes, including lung development; regulation of protein phosphorylation; and regulation of signal transduction. Predicted to localize to several cellular components, including cytoskeleton; cytosol; and nucleus. Human ortholog(s) of this gene implicated in IgA glomerulonephritis. Orthologous to human SPRY2 (sprouty RTK signaling antagonist 2); PARTICIPATES IN fibroblast growth factor signaling pathway; Jak-Stat signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; dibutyl phthalate.
Type: protein-coding
Also known as: LOC306141; sprouty 2; sprouty homolog 2; sprouty homolog 2 (Drosophila)
Homo sapiens (human) : SPRY2 (sprouty RTK signaling antagonist 2)  HGNC  Alliance
Mus musculus (house mouse) : Spry2 (sprouty RTK signaling antagonist 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Spry2 (sprouty RTK signaling antagonist 2)
Pan paniscus (bonobo/pygmy chimpanzee) : SPRY2 (sprouty RTK signaling antagonist 2)
Canis lupus familiaris (dog) : SPRY2 (sprouty RTK signaling antagonist 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Spry2 (sprouty RTK signaling antagonist 2)
Sus scrofa (pig) : SPRY2 (sprouty RTK signaling antagonist 2)
Chlorocebus sabaeus (African green monkey) : SPRY2 (sprouty RTK signaling antagonist 2)
Heterocephalus glaber (naked mole-rat) : Spry2 (sprouty RTK signaling antagonist 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01590,172,769 - 90,177,823 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1590,172,975 - 90,175,802 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01593,662,768 - 93,667,781 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41590,009,109 - 90,011,940 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11590,024,884 - 90,027,720 (-)NCBI
Celera1581,798,483 - 81,801,309 (-)NCBICelera
Cytogenetic Map15q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Spry2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1311472
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.