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Gene: Irf8 (interferon regulatory factor 8) Rattus norvegicus
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Symbol: Irf8
Name: interferon regulatory factor 8
Description: Predicted to have DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II proximal promoter sequence-specific DNA binding activity. Predicted to be involved in several processes, including defense response to other organism; positive regulation of cytokine production; and regulation of transcription by RNA polymerase II. Predicted to localize to the cytoplasm and nucleoplasm. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human IRF8 (interferon regulatory factor 8); PARTICIPATES IN granulocyte-macrophage colony-stimulating factor signaling pathway; INTERACTS WITH (RS)-amphetamine; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 4,4'-diaminodiphenylmethane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: ICSBP; Icsbp1; interferon consensus sequence binding protein 1; LOC292060; transcription factor ICSBP
Orthologs:
Homo sapiens (human) : IRF8 (interferon regulatory factor 8)  HGNC  Alliance
Mus musculus (house mouse) : Irf8 (interferon regulatory factor 8)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Irf8 (interferon regulatory factor 8)
Pan paniscus (bonobo/pygmy chimpanzee) : IRF8 (interferon regulatory factor 8)
Canis lupus familiaris (dog) : IRF8 (interferon regulatory factor 8)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Irf8 (interferon regulatory factor 8)
Sus scrofa (pig) : IRF8 (interferon regulatory factor 8)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01954,314,859 - 54,336,643 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01965,033,704 - 65,055,534 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41951,100,088 - 51,116,730 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11951,104,968 - 51,121,611 (+)NCBI
Celera1948,045,909 - 48,062,560 (+)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on Irf8
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1312024
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.