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Gene: Psenen (presenilin enhancer gamma secretase subunit) Rattus norvegicus
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Symbol: Psenen
Name: presenilin enhancer gamma secretase subunit
Description: Predicted to be involved in several processes, including Notch receptor processing; amyloid-beta formation; and proteolysis. Localizes to the integral component of presynaptic membrane and mitochondrion. Human ortholog(s) of this gene implicated in hidradenitis suppurativa. Orthologous to human PSENEN (presenilin enhancer, gamma-secretase subunit); PARTICIPATES IN Notch signaling pathway; syndecan signaling pathway; Alzheimer's disease pathway; INTERACTS WITH (+)-schisandrin B; bisphenol A; buspirone.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: gamma-secretase subunit PEN-2; liver regeneration-related protein LRRGT00140; LOC292788; LRRGT00140 mRNA; presenilin enhancer 2 homolog; presenilin enhancer 2 homolog (C. elegans); presenilin enhancer protein 2; RGD1312037; similar to RIKEN cDNA 1700023M09
Orthologs:
Homo sapiens (human) : PSENEN (presenilin enhancer, gamma-secretase subunit)  HGNC  Alliance
Mus musculus (house mouse) : Psenen (presenilin enhancer gamma secretase subunit)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Psenen (presenilin enhancer, gamma-secretase subunit)
Pan paniscus (bonobo/pygmy chimpanzee) : PSENEN (presenilin enhancer, gamma-secretase subunit)
Canis lupus familiaris (dog) : PSENEN (presenilin enhancer, gamma-secretase subunit)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Psenen (presenilin enhancer, gamma-secretase subunit)
Sus scrofa (pig) : PSENEN (presenilin enhancer, gamma-secretase subunit)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0189,016,093 - 89,017,449 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0190,170,908 - 90,172,275 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4185,607,051 - 85,608,248 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1185,685,281 - 85,686,137 (-)NCBI
Celera180,186,425 - 80,187,622 (-)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on Psenen
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1312037
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.