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Gene: SYNE3 (spectrin repeat containing nuclear envelope family member 3) Homo sapiens
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Symbol: SYNE3
Name: spectrin repeat containing nuclear envelope family member 3
Description: Exhibits actin filament binding activity. Involved in cytoskeletal anchoring at nuclear membrane; establishment of protein localization to membrane; and regulation of cell shape. Localizes to the meiotic nuclear membrane microtubule tethering complex and nuclear membrane. Biomarker of Huntington's disease; PARTICIPATES IN Huntington's disease pathway; INTERACTS WITH 17beta-estradiol; aflatoxin B1; aflatoxin B2.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: C14orf139; C14orf49; FLJ25605; KASH domain-containing protein 3; KASH3; LINC00341; long intergenic non-protein coding RNA 341; MGC75267; NCRNA00341; Nesp3; nesprin-3; NET53; nuclear envelope spectrin repeat protein 3; spectrin repeat containing, nuclear envelope family member 3; uncharacterized protein C14orf113
Orthologs:
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl1495,407,266 - 95,475,836 (-)Ensembl
GRCh381495,407,266 - 95,516,693 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371495,883,831 - 95,983,000 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361494,953,584 - 95,011,926 (-)NCBINCBI36hg18NCBI36
Build 341494,953,697 - 95,011,926NCBI
Celera1475,939,532 - 75,997,875 (-)NCBI
Cytogenetic Map14q32.13NCBI
HuRef1476,070,099 - 76,127,340 (-)NCBIHuRef
CHM1_11495,821,750 - 95,880,112 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on SYNE3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1312072
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.