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Gene: FEM1B (fem-1 homolog B) Homo sapiens
Symbol: FEM1B
Name: fem-1 homolog B
Description: Exhibits death receptor binding activity. Involved in regulation of DNA damage checkpoint; regulation of extrinsic apoptotic signaling pathway via death domain receptors; and regulation of ubiquitin-protein transferase activity. Localizes to cytosol and nucleoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DKFZp451E0710; F1A-ALPHA; F1AA; fem-1 homolog b (C. elegans); FEM-1-like death receptor binding protein; fem-1-like death receptor-binding protein alpha; fem-1-like in apoptotic pathway protein alpha; FEM1-beta; FIAA; protein fem-1 homolog B
Mus musculus (house mouse) : Fem1b (fem 1 homolog b)  MGI  Alliance
Rattus norvegicus (Norway rat) : Fem1b (fem-1 homolog B)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Fem1b (fem-1 homolog B)
Pan paniscus (bonobo/pygmy chimpanzee) : FEM1B (fem-1 homolog B)
Canis lupus familiaris (dog) : FEM1B (fem-1 homolog B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Fem1b (fem-1 homolog B)
Sus scrofa (pig) : FEM1B (fem-1 homolog B)
Chlorocebus sabaeus (African green monkey) : FEM1B (fem-1 homolog B)
Heterocephalus glaber (naked mole-rat) : Fem1b (fem-1 homolog B)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1568,277,745 - 68,295,862 (+)EnsemblGRCh38hg38GRCh38
GRCh381568,277,745 - 68,295,862 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371568,570,141 - 68,583,640 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361566,357,195 - 66,370,694 (+)NCBINCBI36hg18NCBI36
Build 341566,357,194 - 66,370,693NCBI
Celera1545,455,064 - 45,468,563 (+)NCBI
Cytogenetic Map15q23NCBI
HuRef1545,400,895 - 45,414,396 (+)NCBIHuRef
CHM1_11568,688,084 - 68,706,153 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on FEM1B
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1312083
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.