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Gene: AGO4 (argonaute RISC component 4) Homo sapiens
Symbol: AGO4
Name: argonaute RISC component 4
Description: Exhibits double-stranded RNA binding activity; miRNA binding activity; and single-stranded RNA binding activity. Involved in RNA metabolic process and gene silencing by miRNA. Localizes to the RISC complex; RISC-loading complex; and cytoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: argonaute 4; argonaute 4, RISC catalytic component; argonaute RISC catalytic component 4; argonaute4; eIF-2C 4; eIF2C 4; EIF2C4; eukaryotic translation initiation factor 2C, 4; hAgo4; protein argonaute-4
Mus musculus (house mouse) : Ago4 (argonaute RISC catalytic subunit 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ago4 (argonaute RISC component 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ago4 (argonaute RISC component 4)
Pan paniscus (bonobo/pygmy chimpanzee) : AGO4 (argonaute RISC component 4)
Canis lupus familiaris (dog) : AGO4 (argonaute RISC component 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ago4 (argonaute RISC component 4)
Sus scrofa (pig) : AGO4 (argonaute RISC component 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38135,807,630 - 35,857,890 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37136,273,231 - 36,323,491 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36136,046,415 - 36,093,775 (+)NCBINCBI36hg18NCBI36
Build 34135,942,920 - 35,990,281NCBI
Celera134,548,288 - 34,595,633 (+)NCBI
Cytogenetic Map1p34.3NCBI
HuRef134,391,417 - 34,441,140 (+)NCBIHuRef
CHM1_1136,390,239 - 36,439,851 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on AGO4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1312105
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.