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Gene: AGO4 (argonaute RISC component 4) Homo sapiens
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Symbol: AGO4
Name: argonaute RISC component 4
Description: Exhibits double-stranded RNA binding activity; miRNA binding activity; and single-stranded RNA binding activity. Involved in RNA metabolic process and gene silencing by miRNA. Localizes to the RISC complex; RISC-loading complex; and cytoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: argonaute 4; argonaute 4, RISC catalytic component; argonaute RISC catalytic component 4; argonaute4; eIF-2C 4; eIF2C 4; EIF2C4; eukaryotic translation initiation factor 2C, 4; hAgo4; protein argonaute-4
Orthologs:
Mus musculus (house mouse) : Ago4 (argonaute RISC catalytic subunit 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ago4 (argonaute RISC component 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ago4 (argonaute RISC component 4)
Pan paniscus (bonobo/pygmy chimpanzee) : AGO4 (argonaute RISC component 4)
Canis lupus familiaris (dog) : AGO4 (argonaute RISC component 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ago4 (argonaute RISC component 4)
Sus scrofa (pig) : AGO4 (argonaute RISC component 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38135,807,630 - 35,857,890 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37136,273,231 - 36,323,491 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36136,046,415 - 36,093,775 (+)NCBINCBI36hg18NCBI36
Build 34135,942,920 - 35,990,281NCBI
Celera134,548,288 - 34,595,633 (+)NCBI
Cytogenetic Map1p34.3NCBI
HuRef134,391,417 - 34,441,140 (+)NCBIHuRef
CHM1_1136,390,239 - 36,439,851 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on AGO4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1312105
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.