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Gene: Traf3 (TNF receptor-associated factor 3) Mus musculus
Symbol: Traf3
Name: TNF receptor-associated factor 3
Description: Exhibits protein kinase binding activity. Involved in several processes, including negative regulation of NF-kappaB transcription factor activity; regulation of defense response; and tumor necrosis factor-mediated signaling pathway. Localizes to the CD40 receptor complex and cytoplasmic side of plasma membrane. Human ortholog(s) of this gene implicated in brain disease. Is expressed in several structures, including genitourinary system; hemolymphoid system gland; lower jaw epithelium; lung; and mandibular process. Orthologous to human TRAF3 (TNF receptor associated factor 3); PARTICIPATES IN Toll-like receptor signaling pathway; hepatitis C pathway; Retinoic acid-inducible gene (RIG) I-like receptor signaling pathway; INTERACTS WITH 1,2-dichloroethane; 17alpha-ethynylestradiol; 2,3',4,4',5-Pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI528849; amn; CAP-1; CD40 receptor-associated factor 1; CD40bp; CRAF1; LAP1; RING-type E3 ubiquitin transferase TRAF3; T-BAM; TRAFAMN
Homo sapiens (human) : TRAF3 (TNF receptor associated factor 3)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Traf3 (Tnf receptor-associated factor 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Traf3 (TNF receptor associated factor 3)
Pan paniscus (bonobo/pygmy chimpanzee) : TRAF3 (TNF receptor associated factor 3)
Canis lupus familiaris (dog) : TRAF3 (TNF receptor associated factor 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Traf3 (TNF receptor associated factor 3)
Sus scrofa (pig) : TRAF3 (TNF receptor associated factor 3)
Chlorocebus sabaeus (green monkey) : TRAF3 (TNF receptor associated factor 3)
Heterocephalus glaber (naked mole-rat) : Traf3 (TNF receptor associated factor 3)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl12111,166,370 - 111,267,153 (+)Ensembl
GRCm3812111,166,321 - 111,267,155 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3712112,404,759 - 112,505,359 (+)NCBIGRCm37mm9NCBIm37
MGSCv3612111,667,619 - 111,714,956 (+)NCBImm8
Celera12112,414,118 - 112,461,458 (+)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1260.94NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Traf3
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1312183
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-02-11
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.