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Gene: LIG4 (DNA ligase 4) Homo sapiens
Symbol: LIG4
Name: DNA ligase 4
Description: Exhibits DNA binding activity; DNA ligase (ATP) activity; and protein C-terminus binding activity. Involved in several processes, including DNA metabolic process; cellular response to ionizing radiation; and response to X-ray. Localizes to the condensed chromosome; cytoplasmic ribonucleoprotein granule; and nucleus. Implicated in several diseases, including DNA ligase IV deficiency; colorectal cancer; multiple myeloma; pancreatic cancer; and prostate cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DNA joinase; DNA ligase IV; DNA repair enzyme; LIG4S; ligase IV, DNA, ATP-dependent; polydeoxyribonucleotide synthase [ATP] 4; polynucleotide ligase; sealase
Mus musculus (house mouse) : Lig4 (ligase IV, DNA, ATP-dependent)  MGI  Alliance
Rattus norvegicus (Norway rat) : Lig4 (DNA ligase 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lig4 (DNA ligase 4)
Pan paniscus (bonobo/pygmy chimpanzee) : LIG4 (DNA ligase 4)
Canis lupus familiaris (dog) : LIG4 (DNA ligase 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lig4 (DNA ligase 4)
Sus scrofa (pig) : LIG4 (DNA ligase 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl13108,207,439 - 108,218,368 (-)Ensembl
GRCh3813108,207,442 - 108,218,349 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3713108,859,790 - 108,870,716 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3613107,657,791 - 107,668,717 (-)NCBINCBI36hg18NCBI36
Build 3413107,657,791 - 107,665,883NCBI
Celera1389,704,529 - 89,715,460 (-)NCBI
Cytogenetic Map13q33.3NCBI
HuRef1389,450,570 - 89,461,621 (-)NCBIHuRef
CHM1_113108,828,932 - 108,839,838 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on LIG4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1312194
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-01-07
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.