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Gene: DIS3 (DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease) Homo sapiens
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Symbol: DIS3
Name: DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease
Description: Exhibits 3'-5'-exoribonuclease activity; endonuclease activity; and guanyl-nucleotide exchange factor activity. Involved in CUT catabolic process and rRNA catabolic process. Localizes to the cytosol; nuclear exosome (RNase complex); and nucleoplasm; PARTICIPATES IN ribosome biogenesis pathway; INTERACTS WITH aflatoxin B1; cadmium atom; dicrotophos.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2810028N01Rik; bA555G22.1; DIS3 exosome endoribonuclease and 3'-5' exoribonuclease; DIS3 mitotic control homolog; dis3p; DKFZp667L1817; EXOSC11; exosome complex exonuclease RRP44; exosome component 11; FLJ10484; KIAA1008; MGC33035; mitotic control protein dis3 homolog; protein DIS3 homolog; ribosomal RNA-processing protein 44; RP11-342J4.3; RRP44
Orthologs:
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381372,752,169 - 72,781,900 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371373,329,540 - 73,356,344 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361372,227,541 - 72,254,007 (-)NCBINCBI36hg18NCBI36
Build 341372,227,541 - 72,254,007NCBI
Celera1354,228,002 - 54,254,806 (-)NCBI
Cytogenetic Map13q21.33NCBI
HuRef1354,026,857 - 54,053,683 (-)NCBIHuRef
CHM1_11373,297,230 - 73,323,979 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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Genomics

Comparative Map Data
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Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on DIS3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1312206
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.