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Gene: Arhgef2 (rho/rac guanine nucleotide exchange factor (GEF) 2) Mus musculus
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Symbol: Arhgef2
Name: rho/rac guanine nucleotide exchange factor (GEF) 2
Description: Exhibits Rho guanyl-nucleotide exchange factor activity and microtubule binding activity. Involved in several processes, including establishment of mitotic spindle orientation; generation of neurons; and negative regulation of podosome assembly. Localizes to several cellular components, including the dendritic shaft; podosome; and postsynaptic density. Used to study neurodevelopmental disorder with midbrain and hindbrain malformations. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with midbrain and hindbrain malformations. Is expressed in several structures, including brain; dorsal root ganglion; and testis. Orthologous to human ARHGEF2 (Rho/Rac guanine nucleotide exchange factor 2); PARTICIPATES IN Reelin signaling pathway; INTERACTS WITH 2,3',4,4',5-Pentachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AA408978; GEF; GEF-H1; GEFH1; guanine nucleotide exchange factor H1; LBC'S first cousin; Lbcl1; Lfc; LFP40; lymphoid blast crisis-like 1; mKIAA0651; oncogene LFC; P40; rho guanine nucleotide exchange factor 2; rhobin
Orthologs:
Homo sapiens (human) : ARHGEF2 (Rho/Rac guanine nucleotide exchange factor 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Arhgef2 (Rho/Rac guanine nucleotide exchange factor 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Arhgef2 (Rho/Rac guanine nucleotide exchange factor 2)
Pan paniscus (bonobo/pygmy chimpanzee) : ARHGEF2 (Rho/Rac guanine nucleotide exchange factor 2)
Canis lupus familiaris (dog) : ARHGEF2 (Rho/Rac guanine nucleotide exchange factor 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Arhgef2 (Rho/Rac guanine nucleotide exchange factor 2)
Sus scrofa (pig) : ARHGEF2 (Rho/Rac guanine nucleotide exchange factor 2)
Chlorocebus sabaeus (green monkey) : ARHGEF2 (Rho/Rac guanine nucleotide exchange factor 2)
Heterocephalus glaber (naked mole-rat) : Arhgef2 (Rho/Rac guanine nucleotide exchange factor 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl388,605,966 - 88,648,052 (+)Ensembl
GRCm38388,593,105 - 88,649,532 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37388,425,028 - 88,451,974 (+)NCBIGRCm37mm9NCBIm37
MGSCv36388,707,065 - 88,732,841 (+)NCBImm8
Celera388,656,097 - 88,688,007 (+)NCBICelera
Cytogenetic Map3 F1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
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Molecular Pathway Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Arhgef2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1312227
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-12-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.