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Gene: COA8 (cytochrome c oxidase assembly factor 8) Homo sapiens
Symbol: COA8
Name: cytochrome c oxidase assembly factor 8
Description: Involved in several processes, including mitochondrial respiratory chain complex IV assembly; positive regulation of cytochrome-c oxidase activity; and protein stabilization. Localizes to the matrix side of mitochondrial inner membrane. Implicated in cytochrome-c oxidase deficiency disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: APOP; APOP1; APOPT1; apoptogenic 1; apoptogenic 1, mitochondrial; apoptogenic protein 1; apoptogenic protein 1, mitochondrial; C14orf153; chromosome 14 open reading frame 153; hypothetical protein LOC84334; MGC2562; UPF0671 protein C14orf153
Mus musculus (house mouse) : Apopt1 (apoptogenic, mitochondrial 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Coa8 (cytochrome c oxidase assembly factor 8)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Apopt1 (apoptogenic 1, mitochondrial)
Pan paniscus (bonobo/pygmy chimpanzee) : APOPT1 (apoptogenic 1, mitochondrial)
Canis lupus familiaris (dog) : COA8 (cytochrome c oxidase assembly factor 8)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Apopt1 (apoptogenic 1, mitochondrial)
Sus scrofa (pig) : APOPT1 (apoptogenic 1, mitochondrial)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh3814103,562,960 - 103,593,214 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3714104,029,299 - 104,057,236 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3614103,099,084 - 103,128,277 (+)NCBINCBI36hg18NCBI36
Build 3414103,099,083 - 103,128,261NCBI
Celera1484,083,545 - 84,111,477 (+)NCBI
Cytogenetic Map14q32.33NCBI
HuRef1484,207,680 - 84,235,763 (+)NCBIHuRef
CHM1_114103,967,488 - 103,996,716 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on COA8
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1312327
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-10-29
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.