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Gene: LRP6 (LDL receptor related protein 6) Homo sapiens
Symbol: LRP6
Name: LDL receptor related protein 6
Description: Exhibits several functions, including Wnt-protein binding activity; frizzled binding activity; and low-density lipoprotein particle receptor activity. Involved in several processes, including cellular response to cholesterol; mesenchymal cell differentiation; and regulation of transcription, DNA-templated. Localizes to several cellular components, including Wnt signalosome; Wnt-Frizzled-LRP5/6 complex; and cell surface. Colocalizes with Golgi apparatus; caveola; and early endosome. Implicated in tooth agenesis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ADCAD2; FLJ90062; FLJ90421; low density lipoprotein receptor-related protein 6; low-density lipoprotein receptor-related protein 6; LRP-6; STHAG7
Mus musculus (house mouse) : Lrp6 (low density lipoprotein receptor-related protein 6)  MGI  Alliance
Rattus norvegicus (Norway rat) : Lrp6 (LDL receptor related protein 6)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lrp6 (LDL receptor related protein 6)
Pan paniscus (bonobo/pygmy chimpanzee) : LRP6 (LDL receptor related protein 6)
Canis lupus familiaris (dog) : LRP6 (LDL receptor related protein 6)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lrp6 (LDL receptor related protein 6)
Sus scrofa (pig) : LRP6 (LDL receptor related protein 6)
Chlorocebus sabaeus (African green monkey) : LRP6 (LDL receptor related protein 6)
Heterocephalus glaber (naked mole-rat) : Lrp6 (LDL receptor related protein 6)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1212,116,025 - 12,267,044 (-)EnsemblGRCh38hg38GRCh38
GRCh381212,116,025 - 12,267,044 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371212,268,959 - 12,419,811 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361212,160,226 - 12,311,078 (-)NCBINCBI36hg18NCBI36
Build 341212,164,957 - 12,311,013NCBI
Celera1217,412,009 - 17,562,835 (-)NCBI
Cytogenetic Map12p13.2NCBI
HuRef1212,034,207 - 12,184,947 (-)NCBIHuRef
CHM1_11212,234,005 - 12,384,830 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on LRP6
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1312373
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-07-07
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.