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Gene: LRP6 (LDL receptor related protein 6) Homo sapiens
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Symbol: LRP6
Name: LDL receptor related protein 6
Description: This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.[provided by RefSeq, Dec 2009]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ADCAD2; FLJ90062; FLJ90421; low density lipoprotein receptor-related protein 6; low-density lipoprotein receptor-related protein 6; LRP-6; STHAG7
Orthologs:
Mus musculus (house mouse) : Lrp6 (low density lipoprotein receptor-related protein 6)  MGI  Alliance
Rattus norvegicus (Norway rat) : Lrp6 (LDL receptor related protein 6)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lrp6 (LDL receptor related protein 6)
Pan paniscus (bonobo/pygmy chimpanzee) : LRP6 (LDL receptor related protein 6)
Canis lupus familiaris (dog) : LRP6 (LDL receptor related protein 6)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lrp6 (LDL receptor related protein 6)
Sus scrofa (pig) : LRP6 (LDL receptor related protein 6)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381212,116,025 - 12,267,022 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371212,268,959 - 12,419,811 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361212,160,226 - 12,311,078 (-)NCBINCBI36hg18NCBI36
Build 341212,164,957 - 12,311,013NCBI
Celera1217,412,009 - 17,562,835 (-)NCBI
Cytogenetic Map12p13.2NCBI
HuRef1212,034,207 - 12,184,947 (-)NCBIHuRef
CHM1_11212,234,005 - 12,384,830 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on LRP6
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1312373
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-07-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.