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Gene: HCLS1 (hematopoietic cell-specific Lyn substrate 1) Homo sapiens
Symbol: HCLS1
Name: hematopoietic cell-specific Lyn substrate 1
Description: Exhibits RNA polymerase II transcription factor binding activity and protein kinase binding activity. Involved in several processes, including positive regulation of intracellular signal transduction; positive regulation of protein phosphorylation; and regulation of transcription, DNA-templated. Localizes to several cellular components, including the cytosol; nucleus; and transcription factor complex. Predicted to colocalize with the actin filament; PARTICIPATES IN pathogenic Escherichia coli infection pathway; Shigella infection pathway; INTERACTS WITH acetylsalicylic acid; aflatoxin B1; antirheumatic drug.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: cortactin-like; CTTNL; hematopoietic lineage cell-specific protein; HS1; lckBP1; p75
Mus musculus (house mouse) : Hcls1 (hematopoietic cell specific Lyn substrate 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Hcls1 (hematopoietic cell specific Lyn substrate 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hcls1 (hematopoietic cell-specific Lyn substrate 1)
Pan paniscus (bonobo/pygmy chimpanzee) : HCLS1 (hematopoietic cell-specific Lyn substrate 1)
Canis lupus familiaris (dog) : HCLS1 (hematopoietic cell-specific Lyn substrate 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hcls1 (hematopoietic cell-specific Lyn substrate 1)
Sus scrofa (pig) : HCLS1 (hematopoietic cell-specific Lyn substrate 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl3121,631,399 - 121,660,927 (-)Ensembl
GRCh383121,631,399 - 121,660,903 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh373121,350,246 - 121,379,791 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363122,832,936 - 122,862,405 (-)NCBINCBI36hg18NCBI36
Build 343122,832,936 - 122,862,405NCBI
Celera3119,759,962 - 119,789,755 (-)NCBI
Cytogenetic Map3q13.33NCBI
HuRef3118,724,406 - 118,753,920 (-)NCBIHuRef
CHM1_13121,313,815 - 121,343,339 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on HCLS1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1312380
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.