Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: HDAC2 (histone deacetylase 2) Homo sapiens
Symbol: HDAC2
Name: histone deacetylase 2
Description: Exhibits several functions, including RNA polymerase II-specific DNA-binding transcription factor binding activity; histone deacetylase activity; and histone deacetylase binding activity. Contributes to RNA polymerase II distal enhancer sequence-specific DNA binding activity; RNA polymerase II proximal promoter sequence-specific DNA binding activity; and nucleosomal DNA binding activity. Involved in several processes, including histone deacetylation; positive regulation of macromolecule metabolic process; and regulation of transcription, DNA-templated. Localizes to the cytoplasm and nucleoplasm. Implicated in stomach cancer. Biomarker of several diseases, including alopecia areata; cervix uteri carcinoma in situ; gastrointestinal system cancer (multiple); precursor lymphoblastic lymphoma/leukemia; and pulmonary hypertension.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: HD2; KDAC2; RPD3; transcriptional regulator homolog RPD3; YAF1; YY1-associated factor 1
Mus musculus (house mouse) : Hdac2 (histone deacetylase 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Hdac2 (histone deacetylase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hdac2 (histone deacetylase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : HDAC2 (histone deacetylase 2)
Canis lupus familiaris (dog) : HDAC2 (histone deacetylase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hdac2 (histone deacetylase 2)
Sus scrofa (pig) : HDAC2 (histone deacetylase 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl6113,933,028 - 114,011,308 (-)Ensembl
GRCh386113,933,028 - 113,971,148 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh376114,257,320 - 114,292,359 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366114,364,019 - 114,399,047 (-)NCBINCBI36hg18NCBI36
Build 346114,368,619 - 114,398,967NCBI
Celera6114,998,693 - 115,033,733 (-)NCBI
Cytogenetic Map6q21NCBI
HuRef6111,834,121 - 111,869,161 (-)NCBIHuRef
CHM1_16114,520,179 - 114,555,225 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on HDAC2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1312509
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-01-07
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.