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Gene: ERCC4 (ERCC excision repair 4, endonuclease catalytic subunit) Homo sapiens
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Symbol: ERCC4
Name: ERCC excision repair 4, endonuclease catalytic subunit
Description: Exhibits several functions, including DNA binding activity; identical protein binding activity; and protein C-terminus binding activity. Contributes to 3' overhang single-stranded DNA endodeoxyribonuclease activity and DNA binding activity. Involved in several processes, including DNA metabolic process; negative regulation of double-stranded telomeric DNA binding activity; and negative regulation of telomere maintenance. Localizes to the ERCC4-ERCC1 complex; nuclear chromosome, telomeric region; and nucleotide-excision repair factor 1 complex. Implicated in Fanconi anemia complementation group Q; XFE progeroid syndrome; pancreatic cancer; xeroderma pigmentosum; and xeroderma pigmentosum group F.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DNA excision repair protein ERCC-4; DNA repair endonuclease XPF; DNA repair protein complementing XP-F cells; ERCC11; excision repair cross-complementation group 4; excision repair cross-complementing rodent repair deficiency, complementation group 4; excision-repair, complementing defective, in Chinese hamster; FANCQ; RAD1; xeroderma pigmentosum group F-complementing protein; xeroderma pigmentosum, complementation group F; XFEPS; XPF
Orthologs:
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381613,920,137 - 13,952,348 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371614,014,014 - 14,046,205 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361613,921,524 - 13,949,705 (+)NCBINCBI36hg18NCBI36
Build 341613,921,523 - 13,949,705NCBI
Celera1614,189,206 - 14,221,394 (+)NCBI
Cytogenetic Map16p13.12NCBI
HuRef1613,931,501 - 13,963,699 (+)NCBIHuRef
CHM1_11614,013,994 - 14,046,211 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


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References - uncurated

Genomics

Comparative Map Data
Position Markers
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Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on ERCC4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1312517
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.