Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Ercc4 (excision repair cross-complementing rodent repair deficiency, complementation group 4) Mus musculus
Symbol: Ercc4
Name: excision repair cross-complementing rodent repair deficiency, complementation group 4
Description: Exhibits TFIID-class transcription factor complex binding activity and promoter-specific chromatin binding activity. Predicted to contribute to 3' overhang single-stranded DNA endodeoxyribonuclease activity and DNA binding activity. Involved in DNA repair; UV protection; and regulation of autophagy. Predicted to localize to ERCC4-ERCC1 complex; nuclear chromosome, telomeric region; and nucleotide-excision repair factor 1 complex. Used to study xeroderma pigmentosum group F. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group Q; XFE progeroid syndrome; pancreatic cancer; xeroderma pigmentosum; and xeroderma pigmentosum group F. Is expressed in central nervous system and retina. Orthologous to human ERCC4 (ERCC excision repair 4, endonuclease catalytic subunit); PARTICIPATES IN altered nucleotide excision repair pathway; nucleotide excision repair pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI606920; DNA excision repair protein ERCC-4; DNA repair endonuclease subunit; DNA repair endonuclease XPF; Xpf
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1613,109,684 - 13,150,617 (+)EnsemblGRCm38mm10GRCm38
GRCm381613,109,366 - 13,152,009 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371613,109,829 - 13,152,102 (+)NCBIGRCm37mm9NCBIm37
MGSCv361613,023,314 - 13,062,312 (+)NCBImm8
Celera1613,713,278 - 13,755,555 (+)NCBICelera
Cytogenetic Map16A1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Ercc4
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1312518
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-05-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.