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Gene: Ercc4 (excision repair cross-complementing rodent repair deficiency, complementation group 4) Mus musculus
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Symbol: Ercc4
Name: excision repair cross-complementing rodent repair deficiency, complementation group 4
Description: Exhibits TFIID-class transcription factor complex binding activity and promoter-specific chromatin binding activity. Predicted to contribute to 3' overhang single-stranded DNA endodeoxyribonuclease activity and DNA binding activity. Involved in DNA repair; UV protection; and regulation of autophagy. Predicted to localize to ERCC4-ERCC1 complex; nuclear chromosome, telomeric region; and nucleotide-excision repair factor 1 complex. Used to study xeroderma pigmentosum group F. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group Q; XFE progeroid syndrome; pancreatic cancer; xeroderma pigmentosum; and xeroderma pigmentosum group F. Is expressed in central nervous system and retina. Orthologous to human ERCC4 (ERCC excision repair 4, endonuclease catalytic subunit); PARTICIPATES IN altered nucleotide excision repair pathway; nucleotide excision repair pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI606920; DNA excision repair protein ERCC-4; DNA repair endonuclease subunit; DNA repair endonuclease XPF; Xpf
Orthologs:
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl1613,109,684 - 13,150,617 (+)EnsemblGRCm38mm10GRCm38
GRCm381613,109,366 - 13,152,009 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371613,109,829 - 13,152,102 (+)NCBIGRCm37mm9NCBIm37
MGSCv361613,023,314 - 13,062,312 (+)NCBImm8
Celera1613,713,278 - 13,755,555 (+)NCBICelera
Cytogenetic Map16A1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Ercc4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1312518
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-05-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.