Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: MRTFA (myocardin related transcription factor A) Homo sapiens
Analyze
Symbol: MRTFA
Name: myocardin related transcription factor A
Description: Exhibits actin binding activity and leucine zipper domain binding activity. Involved in positive regulation of transcription via serum response element binding activity and smooth muscle cell differentiation. Localizes to the cytosol and nucleoplasm. Implicated in megakaryocytic leukemia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: basic, SAP and coiled-coil domain; BSAC; MAL; megakaryoblastic leukemia (translocation) 1; megakaryoblastic leukemia 1 protein; megakaryocytic acute leukemia protein; MKL; MKL/myocardin-like protein 1; MKL1; Mkl1 variant 1 Mkl1_S; MRTF-A; myocardin-related transcription factor A; RBM15/MKL1 fusion; RNA-binding motif protein 15/megakaryoblastic leukemia-1 fusion protein
Orthologs:
Mus musculus (house mouse) : Mrtfa (myocardin related transcription factor A)  MGI  Alliance
Rattus norvegicus (Norway rat) : Mrtfa (myocardin related transcription factor A)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mrtfa (myocardin related transcription factor A)
Pan paniscus (bonobo/pygmy chimpanzee) : MRTFA (myocardin related transcription factor A)
Canis lupus familiaris (dog) : MRTFA (myocardin related transcription factor A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mrtfa (myocardin related transcription factor A)
Sus scrofa (pig) : MRTFA (myocardin related transcription factor A)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: MAL (Gene ID: 4118), TIRAP (Gene ID: 114609), and MKL1 (Gene ID: 57591) share the MAL symbol/alias in common. MAL is a widely used alternative name for TIR domain containing adaptor protein (TIRAP) and megakaryoblastic leukemia (translocation) 1 (MKL1). [23 May 2018]
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382240,410,289 - 40,636,719 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372240,806,292 - 41,032,690 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362239,136,238 - 39,362,636 (-)NCBINCBI36hg18NCBI36
Build 342239,130,791 - 39,357,190NCBI
Celera2224,608,353 - 24,836,358 (-)NCBI
Cytogenetic Map22q13.1-q13.2NCBI
HuRef2223,769,395 - 23,994,500 (-)NCBIHuRef
CHM1_12240,765,188 - 40,992,736 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on MRTFA
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1312564
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.