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Gene: KAT6A (lysine acetyltransferase 6A) Homo sapiens
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Symbol: KAT6A
Name: lysine acetyltransferase 6A
Description: This gene encodes a member of the MOZ, YBFR2, SAS2, TIP60 family of histone acetyltransferases. The protein is composed of a nuclear localization domain, a double C2H2 zinc finger domain that binds to acetylated histone tails, a histone acetyl-transferase domain, a glutamate/aspartate-rich region, and a serine- and methionine-rich transactivation domain. It is part of a complex that acetylates lysine-9 residues in histone 3, and in addition, it acts as a co-activator for several transcription factors. Allelic variants of this gene are associated with an autosomal dominant form of cognitive disability. Chromosomal translocations of this gene are associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: histone acetyltransferase KAT6A; histone acetyltransferase MYST3; K(lysine) acetyltransferase 6A; MGC167033; Monocytic leukemia zinc finger protein; MOZ; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3; MRD32; MYST histone acetyltransferase (monocytic leukemia) 3; MYST-3; MYST3; runt-related transcription factor binding protein 2; runt-related transcription factor-binding protein 2; RUNXBP2; ZC2HC6A; zinc finger protein 220; ZNF220
Orthologs:
Mus musculus (house mouse) : Kat6a (K(lysine) acetyltransferase 6A)  MGI  Alliance
Rattus norvegicus (Norway rat) : Kat6a (lysine acetyltransferase 6A)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Kat6a (lysine acetyltransferase 6A)
Pan paniscus (bonobo/pygmy chimpanzee) : KAT6A (lysine acetyltransferase 6A)
Canis lupus familiaris (dog) : KAT6A (lysine acetyltransferase 6A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Kat6a (lysine acetyltransferase 6A)
Sus scrofa (pig) : KAT6A (lysine acetyltransferase 6A)
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Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38841,929,479 - 42,052,026 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37841,786,997 - 41,909,506 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36841,906,154 - 42,028,662 (-)NCBINCBI36hg18NCBI36
Build 34841,907,425 - 42,028,635NCBI
Celera840,736,067 - 40,858,643 (-)NCBI
Cytogenetic Map8p11.21NCBI
HuRef840,314,984 - 40,434,974 (-)NCBIHuRef
CHM1_1841,835,431 - 41,957,840 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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Disease Annotations
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References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on KAT6A
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1312590
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-06-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.