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Gene: EZH2 (enhancer of zeste 2 polycomb repressive complex 2 subunit) Homo sapiens
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Symbol: EZH2
Name: enhancer of zeste 2 polycomb repressive complex 2 subunit
Description: Exhibits chromatin DNA binding activity; histone methyltransferase activity (H3-K27 specific); and promoter-specific chromatin binding activity. Involved in several processes, including histone H3-K27 methylation; negative regulation of transcription, DNA-templated; and regulation of signal transduction. Localizes to the ESC/E(Z) complex; chromosome, telomeric region; and nuclear chromatin. Implicated in Weaver syndrome; glioblastoma multiforme; hematologic cancer (multiple); and stomach cancer. Biomarker of hematologic cancer (multiple); hepatocellular carcinoma; invasive ductal carcinoma; and prostate cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: enhancer of zeste 2; enhancer of zeste homolog 2; ENX-1; ENX1; EZH1; EZH2b; histone-lysine N-methyltransferase EZH2; KMT6; KMT6A; lysine N-methyltransferase 6; MGC9169; WVS; WVS2
Orthologs:
Related Pseudogenes: EZH2P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387148,807,374 - 148,884,344 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh377148,504,464 - 148,581,441 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367148,135,408 - 148,212,347 (-)NCBINCBI36hg18NCBI36
Build 347147,942,122 - 148,019,062NCBI
Celera7143,174,898 - 143,251,832 (-)NCBI
Cytogenetic Map7q36.1NCBI
HuRef7142,583,460 - 142,659,958 (-)NCBIHuRef
CHM1_17148,512,861 - 148,589,845 (-)NCBICHM1_1
CRA_TCAGchr7v27147,842,417 - 147,919,393 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on EZH2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1312683
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-11-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.