Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: EZH2 (enhancer of zeste 2 polycomb repressive complex 2 subunit) Homo sapiens
Symbol: EZH2
Name: enhancer of zeste 2 polycomb repressive complex 2 subunit
CRRD ID: 1312683
Description: Exhibits several functions, including RNA polymerase II transcription corepressor binding activity; histone methyltransferase activity (H3-K27 specific); and promoter-specific chromatin binding activity. Involved in several processes, including histone H3-K27 methylation; negative regulation of transcription, DNA-templated; and regulation of signal transduction. Localizes to ESC/E(Z) complex; chromosome, telomeric region; and nuclear chromatin. Implicated in Weaver syndrome; glioblastoma multiforme; hematologic cancer (multiple); and stomach cancer. Biomarker of hematologic cancer (multiple); hepatocellular carcinoma; invasive ductal carcinoma; and prostate cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: enhancer of zeste 2; enhancer of zeste homolog 2; ENX-1; ENX1; EZH1; EZH2b; histone-lysine N-methyltransferase EZH2; KMT6; KMT6A; lysine N-methyltransferase 6; MGC9169; WVS; WVS2
Related Pseudogenes: EZH2P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl7148,807,383 - 148,884,321 (-)EnsemblGRCh38hg38GRCh38
GRCh387148,807,374 - 148,884,344 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh377148,504,464 - 148,581,441 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367148,135,408 - 148,212,347 (-)NCBINCBI36hg18NCBI36
Build 347147,942,122 - 148,019,062NCBI
Celera7143,174,898 - 143,251,832 (-)NCBI
Cytogenetic Map7q36.1NCBI
HuRef7142,583,460 - 142,659,958 (-)NCBIHuRef
CHM1_17148,512,861 - 148,589,845 (-)NCBICHM1_1
CRA_TCAGchr7v27147,842,417 - 147,919,393 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links