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Gene: Ezh2 (enhancer of zeste 2 polycomb repressive complex 2 subunit) Mus musculus
Symbol: Ezh2
Name: enhancer of zeste 2 polycomb repressive complex 2 subunit
Description: Exhibits several functions, including nucleic acid binding activity; protein methyltransferase activity; and transcription corepressor activity. Involved in several processes, including macromolecule methylation; negative regulation of cell differentiation; and regulation of transcription, DNA-templated. Localizes to the ESC/E(Z) complex and pronucleus. Colocalizes with the nuclear chromatin. Used to study Weaver syndrome and acute lymphocytic leukemia. Human ortholog(s) of this gene implicated in Weaver syndrome; glioblastoma multiforme; hematologic cancer (multiple); and stomach cancer. Is expressed in several structures, including alimentary system; central nervous system; extraembryonic component; genitourinary system; and sensory organ. Orthologous to human EZH2 (enhancer of zeste 2 polycomb repressive complex 2 subunit); PARTICIPATES IN histone modification pathway; methionine cycle/metabolic pathway; INTERACTS WITH 1,1-dichloroethene; 17alpha-ethynylestradiol; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: enhancer of zeste homolog 2; Enx-1; Enx1h; histone-lysine N-methyltransferase EZH2; KIAA4065; KMT6; MGC90723; mKIAA4065
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl647,530,139 - 47,595,341 (-)Ensembl
GRCm38647,530,274 - 47,595,270 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37647,480,273 - 47,545,029 (-)NCBIGRCm37mm9NCBIm37
MGSCv36647,459,867 - 47,524,606 (-)NCBImm8
Celera647,385,379 - 47,451,063 (-)NCBICelera
Cytogenetic Map6 B2.3NCBI
cM Map622.92NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Ezh2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1312684
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-01-21
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.