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![]() Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (-)-quinic acid | multiple interactions | EXP | | 6480464 | [Hydrogen Peroxide co-treated with Quinic Acid analog] results in increased expression of POLD2 mRNA | CTD | PMID:21751221 | 17alpha-ethynylestradiol | increases expression | ISO | RGD:1312694 | 6480464 | Ethinyl Estradiol results in increased expression of POLD2 mRNA | CTD | PMID:17942748 | 17alpha-ethynylestradiol | multiple interactions | ISO | RGD:1312694 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of POLD2 mRNA | CTD | PMID:17942748 | 17alpha-ethynylestradiol | affects expression | ISO | RGD:1312694 | 6480464 | Ethinyl Estradiol affects the expression of POLD2 mRNA | CTD | PMID:17555576 | 17beta-estradiol | increases expression | EXP | | 6480464 | Estradiol results in increased expression of POLD2 mRNA | CTD | PMID:19167446 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:1312694 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of POLD2 mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:1312694 | 6480464 | Tetrachlorodibenzodioxin affects the expression of POLD2 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:1304954 | 6480464 | AHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of POLD2 mRNA] | CTD | PMID:21215274 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:1304954 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of POLD2 mRNA | CTD | PMID:21215274 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:1312694 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of POLD2 mRNA | CTD | PMID:17942748 | 2,4-dinitrotoluene | affects expression | ISO | RGD:1304954 | 6480464 | 2, 4-dinitrotoluene affects the expression of POLD2 mRNA | CTD | PMID:21346803 | 4,4'-diaminodiphenylmethane | decreases expression | ISO | RGD:1312694 | 6480464 | 4, 4'-diaminodiphenylmethane results in decreased expression of POLD2 mRNA | CTD | PMID:18648102 | aflatoxin B1 | decreases expression | ISO | RGD:1312694 | 6480464 | Aflatoxin B1 results in decreased expression of POLD2 mRNA | CTD | PMID:19770486 | aflatoxin B1 | increases expression | ISO | RGD:1304954 | 6480464 | Aflatoxin B1 results in increased expression of POLD2 mRNA | CTD | PMID:23630614 | benzo[e]pyrene | increases methylation | EXP | | 6480464 | benzo(e)pyrene results in increased methylation of POLD2 exon | CTD | PMID:30157460 | bis(2-ethylhexyl) phthalate | multiple interactions | ISO | RGD:1312694 | 6480464 | PPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of POLD2 mRNA] | CTD | PMID:19850644 | bis(2-ethylhexyl) phthalate | increases expression | ISO | RGD:1312694 | 6480464 | Diethylhexyl Phthalate results in increased expression of POLD2 mRNA | CTD | PMID:19850644 | bisphenol A | affects expression | ISO | RGD:1304954 | 6480464 | bisphenol A affects the expression of POLD2 mRNA | CTD | PMID:25181051 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of POLD2 mRNA | CTD | PMID:29275510 | carbon nanotube | increases expression | ISO | RGD:1312694 | 6480464 | Nanotubes, Carbon analog results in increased expression of POLD2 mRNA, Nanotubes, Carbon results in increased expression of POLD2 mRNA | CTD | PMID:25554681 | cobalt dichloride | decreases expression | EXP | | 6480464 | cobaltous chloride results in decreased expression of POLD2 mRNA | CTD | PMID:19320972, PMID:19376846 | coumarin | increases expression | ISO | RGD:1304954 | 6480464 | coumarin results in increased expression of POLD2 mRNA | CTD | PMID:18480146 | coumestrol | multiple interactions | EXP | | 6480464 | [Coumestrol co-treated with 2 more ... | CTD | PMID:19167446 | coumestrol | increases expression | EXP | | 6480464 | Coumestrol results in increased expression of POLD2 mRNA | CTD | PMID:19167446 | dibutyl phthalate | decreases expression | ISO | RGD:1312694 | 6480464 | Dibutyl Phthalate results in decreased expression of POLD2 mRNA | CTD | PMID:17361019, PMID:21266533 | dioxygen | decreases expression | EXP | | 6480464 | Oxygen deficiency results in decreased expression of POLD2 mRNA | CTD | PMID:26516004 | Enterolactone | multiple interactions | EXP | | 6480464 | [Coumestrol co-treated with 2, 3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of POLD2 mRNA | CTD | PMID:19167446 | furan | increases methylation | ISO | RGD:1304954 | 6480464 | furan results in increased methylation of POLD2 gene | CTD | PMID:22079235 | furan | increases expression | ISO | RGD:1304954 | 6480464 | furan results in increased expression of POLD2 mRNA | CTD | PMID:25539665 | guanine | multiple interactions | EXP | | 6480464 | Guanine metabolite results in decreased activity of [POLD1 protein binds to POLD2 protein binds to POLD3 protein binds to POLD4 protein], Guanine metabolite results in decreased activity of [POLD1 protein binds to POLD2 protein binds to POLD4 protein] | CTD | PMID:26010525 | hydrogen peroxide | multiple interactions | EXP | | 6480464 | [Hydrogen Peroxide co-treated with Quinic Acid analog] results in increased expression of POLD2 mRNA, chromium histidinate inhibits the reaction [Hydrogen Peroxide results in increased expression of POLD2 mRNA] | CTD | PMID:19902159, PMID:21751221 | mercury atom | affects expression | EXP | | 6480464 | Mercury affects the expression of POLD2 mRNA | CTD | PMID:16823088 | mercury(0) | affects expression | EXP | | 6480464 | Mercury affects the expression of POLD2 mRNA | CTD | PMID:16823088 | methapyrilene | increases methylation | EXP | | 6480464 | Methapyrilene results in increased methylation of POLD2 exon | CTD | PMID:30157460 | miconazole | increases expression | ISO | RGD:1312694 | 6480464 | Miconazole results in increased expression of POLD2 mRNA | CTD | PMID:27462272 | mifepristone | decreases expression | EXP | | 6480464 | Mifepristone results in decreased expression of POLD2 mRNA | CTD | PMID:17584828 | oxaliplatin | decreases expression | ISO | RGD:1304954 | 6480464 | oxaliplatin results in decreased expression of POLD2 mRNA | CTD | PMID:25729387 | paracetamol | affects expression | ISO | RGD:1312694 | 6480464 | Acetaminophen affects the expression of POLD2 mRNA | CTD | PMID:17562736 | pirinixic acid | decreases expression | ISO | RGD:1312694 | 6480464 | pirinixic acid results in decreased expression of POLD2 mRNA | CTD | PMID:18445702 | pirinixic acid | increases expression | ISO | RGD:1312694 | 6480464 | pirinixic acid results in increased expression of POLD2 mRNA | CTD | PMID:17950772, PMID:18301758 | pirinixic acid | multiple interactions | ISO | RGD:1312694 | 6480464 | PPARA protein promotes the reaction [pirinixic acid results in increased expression of POLD2 mRNA] | CTD | PMID:17950772 | quercetin | decreases expression | EXP | | 6480464 | Quercetin results in decreased expression of POLD2 mRNA | CTD | PMID:15309432 | resveratrol | multiple interactions | EXP | | 6480464 | [Coumestrol co-treated with resveratrol] results in increased expression of POLD2 mRNA | CTD | PMID:19167446 | sirolimus | decreases expression | ISO | RGD:1312694 | 6480464 | Sirolimus results in decreased expression of POLD2 mRNA | CTD | PMID:11355896 | sodium dichromate | increases expression | ISO | RGD:1304954 | 6480464 | sodium bichromate results in increased expression of POLD2 mRNA | CTD | PMID:22110744, PMID:25993096 | tamoxifen | affects expression | ISO | RGD:1312694 | 6480464 | Tamoxifen affects the expression of POLD2 mRNA | CTD | PMID:17555576 | thioacetamide | increases expression | ISO | RGD:1304954 | 6480464 | Thioacetamide results in increased expression of POLD2 mRNA | CTD | PMID:23411599 | topotecan | decreases expression | ISO | RGD:1304954 | 6480464 | Topotecan results in decreased expression of POLD2 mRNA | CTD | PMID:25729387 | trimellitic anhydride | increases expression | ISO | RGD:1312694 | 6480464 | trimellitic anhydride results in increased expression of POLD2 mRNA | CTD | PMID:19042947 | |
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1. | GOA_HUMAN data from the GO Consortium |
2. | Lehmann AR DNA Repair (Amst). 2011 Jul 15;10(7):730-3. doi: 10.1016/j.dnarep.2011.04.023. Epub 2011 May 20. |
3. | Li GM Cell Res. 2008 Jan;18(1):85-98. |
4. | Pipeline to import KEGG annotations from KEGG into RGD |
5. | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
6. | RGD automated import pipeline for gene-chemical interactions |
PubMed | 8530069 9111189 9286699 10559261 10811112 10852724 10978529 11027336 11328591 11473323 11593007 11986310 12171929 12403614 12477932 12522211 12690205 15231747 15342556 15489334 15596820 15670210 16000169 16344560 16479163 16510448 16934752 18029348 18765914 18818516 19237606 20226869 20574454 21079801 21372597 21873635 21988832 22465957 22678362 22863883 23254330 24104479 24169447 24939902 25640309 25662213 25924900 26344197 26496610 26673895 27684187 28514442 28934474 29117863 29229926 29467282 29568061 29961565 30196744 30254264 30463901 |
POLD2 (Homo sapiens - human) |
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Pold2 (Mus musculus - house mouse) |
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Pold2 (Rattus norvegicus - Norway rat) |
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Pold2 (Chinchilla lanigera - long-tailed chinchilla) |
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POLD2 (Pan paniscus - bonobo/pygmy chimpanzee) |
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POLD2 (Canis lupus familiaris - dog) |
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Pold2 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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POLD2 (Sus scrofa - pig) |
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RH71212 |
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csnppold2-pcr1-1 |
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csnppold2-pcr10-1 |
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csnppold2-pcr2-1 |
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csnppold2-pcr3-1 |
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csnppold2-pcr4-1 |
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csnppold2-pcr6-1 |
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csnppold2-pcr7-1 |
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A006F20 |
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MARC_1149-3079:996678917:1 |
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The detailed report is available here: | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer |
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
RefSeq Transcripts | NM_001127218 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
NM_001256879 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
NM_006230 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_024446802 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XR_002956452 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XR_002956453 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XR_002956454 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XR_002956455 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XR_002956456 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XR_002956457 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XR_002956458 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XR_002956459 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
GenBank Nucleotide | AC006454 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
AF185279 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
AF239710 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
AK292347 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
AK298168 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
AK312294 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
AU117477 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
AW732014 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
AY116646 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
BC000459 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
BC030001 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
BP224472 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
CH236960 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
CH471128 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
DB025069 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
U21090 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
RefSeq Acc Id: | NM_001127218 ⟹ NP_001120690 | |||||||||||||||||||||||||||||
RefSeq Status: | REVIEWED | |||||||||||||||||||||||||||||
Type: | CODING | |||||||||||||||||||||||||||||
Position: |
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Sequence: |
GAGTTGCGGCGATGGGCGGGGCAGGCGCGCGGGGATTGGCGGGATGCGGCGCGCCGCGCGGGTGhide sequence |
RefSeq Acc Id: | NM_001256879 ⟹ NP_001243808 | |||||||||||||||||||||||||||||
RefSeq Status: | REVIEWED | |||||||||||||||||||||||||||||
Type: | CODING | |||||||||||||||||||||||||||||
Position: |
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Sequence: |
GAGTGGGGTCCAGGGAAACGGGGTCAGCTGGGGGTGGCAGTTCCAGGCCGCGAGGCCGGGCTCChide sequence |
RefSeq Acc Id: | NM_006230 ⟹ NP_006221 | ||||||||||||||||||||||||||||||||||
RefSeq Status: | REVIEWED | ||||||||||||||||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||||||||||||||||
Position: |
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Sequence: |
GAGTTGCGGCGATGGGCGGGGCAGGCGCGCGGGGATTGGCGGGATGCGGCGCGCCGCGCGTGAAhide sequence |
RefSeq Acc Id: | XM_024446802 ⟹ XP_024302570 | |||||||||
RefSeq Status: | ||||||||||
Type: | CODING | |||||||||
Position: |
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Sequence: |
GGGCAGGCGCGCGGGGATTGGCGGGATGCGGCGCGCCGCGCGTATCCTTTGGGTGCAGTGAGAChide sequence |
RefSeq Acc Id: | XR_002956452 | |||||||||
RefSeq Status: | ||||||||||
Type: | NON-CODING | |||||||||
Position: |
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Sequence: |
CGGCGATGGGCGGGGCAGGCGCGCGGGGATTGGCGGGATGCGGCGCGCCGCGCGTGAACCTCCThide sequence |
RefSeq Acc Id: | XR_002956453 | |||||||||
RefSeq Status: | ||||||||||
Type: | NON-CODING | |||||||||
Position: |
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Sequence: |
AGTGGTCGGCGGGATGAGGCGCCTGGTGACGGACGGGGCGAGGAGGGCAGCGATTGTGAACCTChide sequence |
RefSeq Acc Id: | XR_002956454 | |||||||||
RefSeq Status: | ||||||||||
Type: | NON-CODING | |||||||||
Position: |
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Sequence: |
CAGGCCGCGAGGCCGGGCTCCTGGGTCGGTGGGCTGGTGTCTTGGCGGACGTCCCGCAGCTGCChide sequence |
RefSeq Acc Id: | XR_002956455 | |||||||||
RefSeq Status: | ||||||||||
Type: | NON-CODING | |||||||||
Position: |
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Sequence: |
ACGGGGTCAGCTGGGGGTGGCAGTTCCAGGCCGCGAGGCCGGGCTCCTGGGTCGGTGGGCTGGThide sequence |
RefSeq Acc Id: | XR_002956456 | |||||||||
RefSeq Status: | ||||||||||
Type: | NON-CODING | |||||||||
Position: |
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Sequence: |
GAGTGGGGTCCAGGGAAACGGGGTCAGCTGGGGGTGGCAGTTCCAGGCCGCGAGGCCGGGCTCChide sequence |
RefSeq Acc Id: | XR_002956457 | |||||||||
RefSeq Status: | ||||||||||
Type: | NON-CODING | |||||||||
Position: |
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Sequence: |
AGGCGCGCGGGGATTGGCGGGATGCGGCGCGCCGCGCGTATCCTTTGGGTGCAGTGAGACACCAhide sequence |
RefSeq Acc Id: | XR_002956458 | |||||||||
RefSeq Status: | ||||||||||
Type: | NON-CODING | |||||||||
Position: |
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Sequence: |
CAGGCCGCGAGGCCGGGCTCCTGGGTCGGTGGGCTGGTGTCTTGGCGGACGTCCCGCAGCTGCChide sequence |
RefSeq Acc Id: | XR_002956459 | |||||||||
RefSeq Status: | ||||||||||
Type: | NON-CODING | |||||||||
Position: |
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Sequence: |
ACTATTATTTCAATTGTATGTGAAAAAATTATTGGGATATTCTTTGTACTATTCTTAGAAATCChide sequence |
Protein RefSeqs | NP_001120690 | (Get FASTA) | NCBI Sequence Viewer |
NP_001243808 | (Get FASTA) | NCBI Sequence Viewer | |
NP_006221 | (Get FASTA) | NCBI Sequence Viewer | |
XP_024302570 | (Get FASTA) | NCBI Sequence Viewer | |
GenBank Protein | AAC50216 | (Get FASTA) | NCBI Sequence Viewer |
AAG09763 | (Get FASTA) | NCBI Sequence Viewer | |
AAH00459 | (Get FASTA) | NCBI Sequence Viewer | |
AAM51148 | (Get FASTA) | NCBI Sequence Viewer | |
BAF85036 | (Get FASTA) | NCBI Sequence Viewer | |
BAG35221 | (Get FASTA) | NCBI Sequence Viewer | |
BAG60440 | (Get FASTA) | NCBI Sequence Viewer | |
EAL23767 | (Get FASTA) | NCBI Sequence Viewer | |
EAW61118 | (Get FASTA) | NCBI Sequence Viewer | |
P49005 | (Get FASTA) | NCBI Sequence Viewer |
RefSeq Acc Id: | NP_006221 ⟸ NM_006230 |
- Peptide Label: | isoform 2 |
- UniProtKB: | P49005 (UniProtKB/Swiss-Prot), A0A087WWF6 (UniProtKB/TrEMBL) |
- Sequence: |
MGGAGARGLAGCGAPRVNLLGLGEAVWTKQVRSVAMFSEQAAQRAHTLLSPPSANNATFARVPVhide sequence |
RefSeq Acc Id: | NP_001120690 ⟸ NM_001127218 |
- Peptide Label: | isoform 1 |
- UniProtKB: | P49005 (UniProtKB/Swiss-Prot) |
- Sequence: |
MFSEQAAQRAHTLLSPPSANNATFARVPVATYTNSSQPFRLGERSFSRQYAHIYATRLIQMRPFhide sequence |
RefSeq Acc Id: | NP_001243808 ⟸ NM_001256879 |
- Peptide Label: | isoform 1 |
- UniProtKB: | P49005 (UniProtKB/Swiss-Prot) |
- Sequence: |
MFSEQAAQRAHTLLSPPSANNATFARVPVATYTNSSQPFRLGERSFSRQYAHIYATRLIQMRPFhide sequence |
RefSeq Acc Id: | XP_024302570 ⟸ XM_024446802 |
- Peptide Label: | isoform X1 |
- Sequence: |
MFSEQAAQRAHTLLSPPSANNATFARVPVATYTNSSQPFRLGERSFSRQYAHIYATRLIQMRPFhide sequence |
RGD ID: | 6806031 | |||||||||
Promoter ID: | HG_KWN:57214 | |||||||||
Type: | Non-CpG | |||||||||
SO ACC ID: | SO:0000170 | |||||||||
Source: | MPROMDB | |||||||||
Tissues & Cell Lines: | CD4+TCell, HeLa_S3, Jurkat, K562, NB4 | |||||||||
Transcripts: | OTTHUMT00000343143 | |||||||||
Position: |
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RGD ID: | 6806032 | |||||||||
Promoter ID: | HG_KWN:57215 | |||||||||
Type: | CpG-Island | |||||||||
SO ACC ID: | SO:0000170 | |||||||||
Source: | MPROMDB | |||||||||
Tissues & Cell Lines: | HeLa_S3 | |||||||||
Transcripts: | OTTHUMT00000343144 | |||||||||
Position: |
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RGD ID: | 6806029 | |||||||||
Promoter ID: | HG_KWN:57216 | |||||||||
Type: | CpG-Island | |||||||||
SO ACC ID: | SO:0000170 | |||||||||
Source: | MPROMDB | |||||||||
Tissues & Cell Lines: | HeLa_S3, K562, NB4 | |||||||||
Transcripts: | OTTHUMT00000343140, OTTHUMT00000343142 | |||||||||
Position: |
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RGD ID: | 7210493 | |||||||||
Promoter ID: | EPDNEW_H10993 | |||||||||
Type: | initiation region | |||||||||
Name: | POLD2_1 | |||||||||
Description: | DNA polymerase delta 2, accessory subunit | |||||||||
SO ACC ID: | SO:0000170 | |||||||||
Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | |||||||||
Experiment Methods: | Single-end sequencing. | |||||||||
Position: |
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RGD ID: | 6805525 | |||||||||
Promoter ID: | HG_KWN:57217 | |||||||||
Type: | CpG-Island | |||||||||
SO ACC ID: | SO:0000170 | |||||||||
Source: | MPROMDB | |||||||||
Tissues & Cell Lines: | HeLa_S3, NB4 | |||||||||
Transcripts: | ENST00000223361, OTTHUMT00000343138, OTTHUMT00000343139, UC003TKE.2 | |||||||||
Position: |
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RGD ID: | 6806028 | |||||||||
Promoter ID: | HG_KWN:57218 | |||||||||
Type: | CpG-Island | |||||||||
SO ACC ID: | SO:0000170 | |||||||||
Source: | MPROMDB | |||||||||
Tissues & Cell Lines: | CD4+TCell, CD4+TCell_12Hour, CD4+TCell_2Hour, HeLa_S3, Jurkat, K562, Lymphoblastoid, NB4 | |||||||||
Transcripts: | NM_001127218, NM_006230, OTTHUMT00000250994, OTTHUMT00000343132, OTTHUMT00000343133, OTTHUMT00000343134, OTTHUMT00000343135, OTTHUMT00000343136, OTTHUMT00000343137 | |||||||||
Position: |
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RGD ID: | 6851228 | |||||||||
Promoter ID: | EP73412 | |||||||||
Type: | multiple initiation site | |||||||||
Name: | HS_POLD2 | |||||||||
Description: | Polymerase (DNA directed), delta 2, regulatory subunit 50kDa. | |||||||||
SO ACC ID: | SO:0000170 | |||||||||
Source: | EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | |||||||||
Experiment Methods: | NEDO full length human cDNA sequencing project.; Oligo-capping | |||||||||
Position: |
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Name | Type | Condition(s) | Position(s) | Clinical significance |
GRCh38/hg38 7p22.3-q36.3(chr7:53985-159282531)x1 | copy number loss | Ambiguous genitalia [RCV000052250]|See cases [RCV000052250] | Chr7:53985..159282531 [GRCh38] Chr7:53985..159075220 [GRCh37] Chr7:149068..158767981 [NCBI36] Chr7:7p22.3-q36.3 |
pathogenic |
GRCh38/hg38 7p14.1-12.3(chr7:39814159-45749735)x1 | copy number loss | 2-3 toe syndactyly [RCV000053132]|See cases [RCV000053132] | Chr7:39814159..45749735 [GRCh38] Chr7:39853758..45789334 [GRCh37] Chr7:39820283..45755859 [NCBI36] Chr7:7p14.1-12.3 |
pathogenic |
GRCh38/hg38 7p14.3-q11.21(chr7:33328312-62377476)x3 | copy number gain | Nonsyndromic microcephaly [RCV000053532]|See cases [RCV000053532] | Chr7:33328312..62377476 [GRCh38] Chr7:33367924..61831899 [GRCh37] Chr7:33334449..61469334 [NCBI36] Chr7:7p14.3-q11.21 |
pathogenic |
NM_001129.4(AEBP1):c.2885C>T (p.Pro962Leu) | single nucleotide variant | Malignant melanoma [RCV000067880] | Chr7:44113669 [GRCh38] Chr7:44153268 [GRCh37] Chr7:44119793 [NCBI36] Chr7:7p13 |
not provided |
NM_001127218.2(POLD2):c.220+481T>C | single nucleotide variant | Lung cancer [RCV000106058] | Chr7:44121353 [GRCh38] Chr7:44160952 [GRCh37] Chr7:7p13 |
uncertain significance |
GRCh38/hg38 7p22.3-q36.3(chr7:54185-159282390)x1 | copy number loss | See cases [RCV000135401] | Chr7:54185..159282390 [GRCh38] Chr7:54185..159075079 [GRCh37] Chr7:149268..158767840 [NCBI36] Chr7:7p22.3-q36.3 |
pathogenic |
GRCh38/hg38 7p14.1-11.2(chr7:40534157-56107122)x1 | copy number loss | See cases [RCV000136092] | Chr7:40534157..56107122 [GRCh38] Chr7:40573756..56174815 [GRCh37] Chr7:40540281..56142309 [NCBI36] Chr7:7p14.1-11.2 |
pathogenic |
GRCh38/hg38 7p14.1-12.1(chr7:40020598-50543500)x1 | copy number loss | See cases [RCV000136904] | Chr7:40020598..50543500 [GRCh38] Chr7:40060197..50611198 [GRCh37] Chr7:40026722..50578692 [NCBI36] Chr7:7p14.1-12.1 |
pathogenic |
GRCh38/hg38 7p14.1-12.3(chr7:37303478-48660738)x1 | copy number loss | See cases [RCV000137139] | Chr7:37303478..48660738 [GRCh38] Chr7:37343082..48700334 [GRCh37] Chr7:37309607..48670880 [NCBI36] Chr7:7p14.1-12.3 |
pathogenic |
GRCh38/hg38 7p14.1-13(chr7:39063400-45363096)x1 | copy number loss | See cases [RCV000137305] | Chr7:39063400..45363096 [GRCh38] Chr7:39103000..45402695 [GRCh37] Chr7:39069525..45369220 [NCBI36] Chr7:7p14.1-13 |
pathogenic |
GRCh38/hg38 7p14.1-13(chr7:38177999-45304100)x1 | copy number loss | See cases [RCV000142297] | Chr7:38177999..45304100 [GRCh38] Chr7:38217601..45343699 [GRCh37] Chr7:38184126..45310224 [NCBI36] Chr7:7p14.1-13 |
pathogenic |
GRCh37/hg19 7p22.3-q36.3(chr7:43360-159119707)x1 | copy number loss | See cases [RCV000446044] | Chr7:43360..159119707 [GRCh37] Chr7:7p22.3-q36.3 |
pathogenic |
GRCh37/hg19 7p13(chr7:43884184-44297732)x3 | copy number gain | not provided [RCV000584852] | Chr7:43884184..44297732 [GRCh37] Chr7:7p13 |
likely benign |
TMEM106B-BRAF fusion | deletion | Pleomorphic xanthoastrocytoma [RCV000454357] | Chr7:12258147..140494267 [GRCh37] Chr7:7p21.3-q34 |
pathogenic |
GRCh37/hg19 7p14.1-12.3(chr7:40350383-47034422)x1 | copy number loss | See cases [RCV000446941] | Chr7:40350383..47034422 [GRCh37] Chr7:7p14.1-12.3 |
pathogenic |
GRCh37/hg19 7p14.3-13(chr7:32911003-44576005)x1 | copy number loss | See cases [RCV000446955] | Chr7:32911003..44576005 [GRCh37] Chr7:7p14.3-13 |
pathogenic |
GRCh37/hg19 7p21.3-12.1(chr7:11048840-52863626)x3 | copy number gain | See cases [RCV000512091] | Chr7:11048840..52863626 [GRCh37] Chr7:7p21.3-12.1 |
pathogenic |
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707) | copy number gain | See cases [RCV000510686] | Chr7:43361..159119707 [GRCh37] Chr7:7p22.3-q36.3 |
pathogenic |
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707)x3 | copy number gain | See cases [RCV000511549] | Chr7:43361..159119707 [GRCh37] Chr7:7p22.3-q36.3 |
pathogenic |
NC_000007.13:g.(20954043_21001537)_(114528369_114556605)inv | inversion | Speech-language disorder 1 [RCV000234948] | Chr7:21001537..114528369 [GRCh37] Chr7:7p15.3-q31.1 |
pathogenic |
GRCh37/hg19 7p22.3-q36.3(chr7:10704-159122532)x3 | copy number gain | not provided [RCV000746278] | Chr7:10704..159122532 [GRCh37] Chr7:7p22.3-q36.3 |
pathogenic |
GRCh37/hg19 7p22.3-q36.3(chr7:44935-159126310)x3 | copy number gain | not provided [RCV000746280] | Chr7:44935..159126310 [GRCh37] Chr7:7p22.3-q36.3 |
pathogenic |
GRCh37/hg19 7p22.3-q36.3(chr7:10365-159119707)x3 | copy number gain | not provided [RCV000848126] | Chr7:10365..159119707 [GRCh37] Chr7:7p22.3-q36.3 |
pathogenic |
Database | Acc Id | Source(s) |
AGR Gene | HGNC:9176 | AgrOrtholog |
COSMIC | POLD2 | COSMIC |
Ensembl Genes | ENSG00000106628 | ENTREZGENE, UniProtKB/Swiss-Prot |
Ensembl Protein | ENSP00000223361 | ENTREZGENE, UniProtKB/TrEMBL |
ENSP00000386105 | ENTREZGENE, UniProtKB/Swiss-Prot | |
ENSP00000389816 | UniProtKB/TrEMBL | |
ENSP00000395231 | ENTREZGENE, UniProtKB/Swiss-Prot | |
ENSP00000397461 | UniProtKB/TrEMBL | |
ENSP00000399447 | UniProtKB/TrEMBL | |
ENSP00000406702 | UniProtKB/TrEMBL | |
ENSP00000416203 | UniProtKB/TrEMBL | |
ENSP00000480186 | ENTREZGENE, UniProtKB/TrEMBL | |
Ensembl Transcript | ENST00000223361 | ENTREZGENE, UniProtKB/TrEMBL |
ENST00000406581 | ENTREZGENE, UniProtKB/Swiss-Prot | |
ENST00000418438 | UniProtKB/TrEMBL | |
ENST00000433715 | UniProtKB/TrEMBL | |
ENST00000436400 | UniProtKB/TrEMBL | |
ENST00000436844 | UniProtKB/TrEMBL | |
ENST00000452185 | ENTREZGENE, UniProtKB/Swiss-Prot | |
ENST00000456038 | UniProtKB/TrEMBL | |
ENST00000610533 | ENTREZGENE, UniProtKB/TrEMBL | |
GTEx | ENSG00000106628 | GTEx |
HGNC ID | HGNC:9176 | ENTREZGENE |
Human Proteome Map | POLD2 | Human Proteome Map |
InterPro | DNA_pol_a/d/e_bsu | UniProtKB/Swiss-Prot |
DNA_pol_D_N | UniProtKB/Swiss-Prot | |
DNA_pol_delta/II_ssu | UniProtKB/Swiss-Prot | |
PolD2_C | UniProtKB/Swiss-Prot | |
KEGG Report | hsa:5425 | UniProtKB/Swiss-Prot |
NCBI Gene | 5425 | ENTREZGENE |
OMIM | 600815 | OMIM |
PANTHER | PTHR10416 | UniProtKB/Swiss-Prot |
Pfam | DNA_pol_D_N | UniProtKB/Swiss-Prot |
DNA_pol_E_B | UniProtKB/Swiss-Prot | |
PharmGKB | PA33497 | PharmGKB |
UniGene | Hs.306791 | ENTREZGENE |
Hs.740138 | ENTREZGENE | |
UniProt | A0A087WWF6 | ENTREZGENE, UniProtKB/TrEMBL |
C9IZD2_HUMAN | UniProtKB/TrEMBL | |
C9J8Z7_HUMAN | UniProtKB/TrEMBL | |
C9JHC7_HUMAN | UniProtKB/TrEMBL | |
C9JLE1_HUMAN | UniProtKB/TrEMBL | |
DPOD2_HUMAN | UniProtKB/Swiss-Prot | |
F8W8R3_HUMAN | UniProtKB/TrEMBL | |
H7C1B3_HUMAN | UniProtKB/TrEMBL | |
P49005 | ENTREZGENE | |
UniProt Secondary | A4D2J4 | UniProtKB/Swiss-Prot |
B2R5S4 | UniProtKB/Swiss-Prot |
Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
---|---|---|---|---|---|---|---|
2016-08-02 | POLD2 | DNA polymerase delta 2, accessory subunit | POLD2 | DAN polymerase delta 2, accessory subunit | Symbol and/or name change | 5135510 | APPROVED |
2016-07-19 | POLD2 | DAN polymerase delta 2, accessory subunit | POLD2 | polymerase (DNA) delta 2, accessory subunit | Symbol and/or name change | 5135510 | APPROVED |
2016-03-07 | POLD2 | polymerase (DNA) delta 2, accessory subunit | POLD2 | polymerase (DNA directed), delta 2, accessory subunit | Symbol and/or name change | 5135510 | APPROVED |
2012-05-29 | POLD2 | polymerase (DNA directed), delta 2, accessory subunit | POLD2 | polymerase (DNA directed), delta 2, regulatory subunit 50kDa | Symbol and/or name change | 5135510 | APPROVED |
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More on POLD2 | |
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Alliance Gene |
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NCBI Gene |
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Ensembl Gene |
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JBrowse: hg19 hg38 |
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HGNC Report |
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NCBI Genome Data Viewer |
CRRD Object Information | |
CRRD ID: | 1312693 |
Created: | 2005-01-12 |
Species: | Homo sapiens |
Last Modified: | 2019-11-26 |
Status: | ACTIVE |
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.