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Gene: Usp8 (ubiquitin specific peptidase 8) Mus musculus
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Symbol: Usp8
Name: ubiquitin specific peptidase 8
Description: Exhibits thiol-dependent ubiquitin-specific protease activity. Involved in Ras protein signal transduction; endosome organization; and protein deubiquitination. Localizes to the cytosol; extrinsic component of endosome membrane; and midbody. Colocalizes with the acrosomal vesicle. Human ortholog(s) of this gene implicated in ACTH-secreting pituitary adenoma. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and sensory organ. Orthologous to human USP8 (ubiquitin specific peptidase 8); PARTICIPATES IN mitochondrial autophagy pathway; endocytosis pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; Aroclor 1254.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI574262; AW557536; deubiquitinating enzyme 8; mKIAA0055; mUBPy; putative deubiquitinating enzyme; ubiquitin carboxyl-terminal hydrolase 8; ubiquitin isopeptidase Y; ubiquitin specific protease 8; ubiquitin thioesterase 8; ubiquitin thiolesterase 8; ubiquitin-specific-processing protease 8; Ubpy
Orthologs:
Homo sapiens (human) : USP8 (ubiquitin specific peptidase 8)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Usp8 (ubiquitin specific peptidase 8)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Usp8 (ubiquitin specific peptidase 8)
Pan paniscus (bonobo/pygmy chimpanzee) : USP8 (ubiquitin specific peptidase 8)
Canis lupus familiaris (dog) : USP8 (ubiquitin specific peptidase 8)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Usp8 (ubiquitin specific peptidase 8)
Sus scrofa (pig) : USP8 (ubiquitin specific peptidase 8)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm382126,707,201 - 126,759,314 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv372126,533,099 - 126,585,033 (+)NCBIGRCm37mm9NCBIm37
MGSCv362126,398,804 - 126,450,738 (+)NCBImm8
Celera2127,946,923 - 127,999,169 (+)NCBICelera
Cytogenetic Map2 F1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Usp8
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1312731
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-09-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.