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Gene: Usp8 (ubiquitin specific peptidase 8) Mus musculus
Symbol: Usp8
Name: ubiquitin specific peptidase 8
Description: Exhibits thiol-dependent ubiquitin-specific protease activity. Involved in Ras protein signal transduction; endosome organization; and protein deubiquitination. Localizes to the cytosol; extrinsic component of endosome membrane; and midbody. Colocalizes with the acrosomal vesicle. Human ortholog(s) of this gene implicated in ACTH-secreting pituitary adenoma. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and sensory organ. Orthologous to human USP8 (ubiquitin specific peptidase 8); PARTICIPATES IN mitochondrial autophagy pathway; endocytosis pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; Aroclor 1254.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI574262; AW557536; deubiquitinating enzyme 8; mKIAA0055; mUBPy; putative deubiquitinating enzyme; ubiquitin carboxyl-terminal hydrolase 8; ubiquitin isopeptidase Y; ubiquitin specific protease 8; ubiquitin thioesterase 8; ubiquitin thiolesterase 8; ubiquitin-specific-processing protease 8; Ubpy
Homo sapiens (human) : USP8 (ubiquitin specific peptidase 8)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Usp8 (ubiquitin specific peptidase 8)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Usp8 (ubiquitin specific peptidase 8)
Pan paniscus (bonobo/pygmy chimpanzee) : USP8 (ubiquitin specific peptidase 8)
Canis lupus familiaris (dog) : USP8 (ubiquitin specific peptidase 8)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Usp8 (ubiquitin specific peptidase 8)
Sus scrofa (pig) : USP8 (ubiquitin specific peptidase 8)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm382126,707,201 - 126,759,314 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv372126,533,099 - 126,585,033 (+)NCBIGRCm37mm9NCBIm37
MGSCv362126,398,804 - 126,450,738 (+)NCBImm8
Celera2127,946,923 - 127,999,169 (+)NCBICelera
Cytogenetic Map2 F1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Usp8
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1312731
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.