Gene: HEYL (hes related family bHLH transcription factor with YRPW motif like) Homo sapiens
Symbol: HEYL
Name: hes related family bHLH transcription factor with YRPW motif like
Description: This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The sequence of the encoded protein contains a conserved bHLH and orange domain, but its YRPW motif has diverged from other HESR family members. It is thought to be an effector of Notch signaling and a regulator of cell fate decisions. Alternatively spliced transcript variants have been found, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: bHLHb33; class B basic helix-loop-helix protein 33; hairy-related transcription factor 3; hairy/enhancer-of-split related with YRPW motif 3; hairy/enhancer-of-split related with YRPW motif-like protein; hes related family bHLH transcription factor with YRPW motif-like; hes-related family bHLH transcription factor with YRPW motif-like; HESR3; HEY-like protein; HEY3; hHeyL; hHRT3; HRT-3; HRT3; MGC12623
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38139,623,431 - 39,639,676 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37140,089,103 - 40,105,348 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36139,861,690 - 39,877,935 (-)NCBINCBI36hg18NCBI36
Build 34139,758,917 - 39,774,411NCBI
Celera138,370,855 - 38,387,100 (-)NCBI
Cytogenetic Map1p34.2NCBI
HuRef138,207,488 - 38,223,733 (-)NCBIHuRef
CHM1_1140,204,476 - 40,220,725 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on HEYL
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1312805
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-05-14
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.