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Gene: PNN (pinin, desmosome associated protein) Homo sapiens
Symbol: PNN
Name: pinin, desmosome associated protein
Description: Exhibits RNA binding activity. Predicted to be involved in cell adhesion and mRNA splicing, via spliceosome. Localizes to the catalytic step 2 spliceosome and nuclear speck. Colocalizes with the exon-exon junction complex; PARTICIPATES IN mRNA decay pathway; spliceosome pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 140 kDa nuclear and cell adhesion-related phosphoprotein; desmosome-associated protein; domain-rich serine protein; DRS; DRSP; melanoma metastasis clone A protein; memA; neutrophil protein; nuclear protein SDK3; pinin; SDK3; SR-like protein
Mus musculus (house mouse) : Pnn (pinin)  MGI  Alliance
Rattus norvegicus (Norway rat) : Pnn (pinin, desmosome associated protein)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pnn (pinin, desmosome associated protein)
Pan paniscus (bonobo/pygmy chimpanzee) : PNN (pinin, desmosome associated protein)
Canis lupus familiaris (dog) : PNN (pinin, desmosome associated protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pnn (pinin, desmosome associated protein)
Sus scrofa (pig) : PNN (pinin, desmosome associated protein)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1439,175,183 - 39,183,220 (+)Ensembl
GRCh381439,175,254 - 39,183,220 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371439,644,387 - 39,652,422 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361438,714,138 - 38,722,173 (+)NCBINCBI36hg18NCBI36
Build 341438,714,150 - 38,721,178NCBI
Celera1419,509,004 - 19,517,039 (+)NCBI
Cytogenetic Map14q21.1NCBI
HuRef1419,758,590 - 19,766,626 (+)NCBIHuRef
CHM1_11439,642,991 - 39,651,026 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on PNN
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1313105
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.