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Gene: HAVCR2 (hepatitis A virus cellular receptor 2) Homo sapiens
Symbol: HAVCR2
Name: hepatitis A virus cellular receptor 2
Description: Predicted to have metal ion binding activity. Involved in several processes, including negative regulation of cytokine production; negative regulation of leukocyte activation; and positive regulation of cytokine production. Localizes to cell surface. Implicated in renal cell carcinoma. Biomarker of cystic fibrosis and pulmonary tuberculosis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CD366; FLJ14428; HAVcr-2; kidney injury molecule-3; KIM-3; SPTCL; T cell immunoglobulin mucin 3; T cell immunoglobulin mucin-3; T-cell immunoglobulin and mucin domain-containing protein 3; T-cell immunoglobulin mucin family member 3; T-cell immunoglobulin mucin receptor 3; T-cell membrane protein 3; Tim-3; TIM3; TIMD-3; TIMD3
Mus musculus (house mouse) : Havcr2 (hepatitis A virus cellular receptor 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Havcr2 (hepatitis A virus cellular receptor 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Havcr2 (hepatitis A virus cellular receptor 2)
Pan paniscus (bonobo/pygmy chimpanzee) : HAVCR2 (hepatitis A virus cellular receptor 2)
Canis lupus familiaris (dog) : HAVCR2 (hepatitis A virus cellular receptor 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Havcr2 (hepatitis A virus cellular receptor 2)
Sus scrofa (pig) : HAVCR2 (hepatitis A virus cellular receptor 2)
Chlorocebus sabaeus (African green monkey) : HAVCR2 (hepatitis A virus cellular receptor 2)
Heterocephalus glaber (naked mole-rat) : Havcr2 (hepatitis A virus cellular receptor 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl5157,085,832 - 157,142,869 (-)EnsemblGRCh38hg38GRCh38
GRCh385157,085,832 - 157,109,044 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh375156,512,843 - 156,536,248 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365156,445,421 - 156,468,716 (-)NCBINCBI36hg18NCBI36
Build 345156,445,420 - 156,468,716NCBI
Celera5152,539,374 - 152,562,664 (-)NCBI
Cytogenetic Map5q33.3NCBI
HuRef5151,601,069 - 151,624,237 (-)NCBIHuRef
CHM1_15155,945,610 - 155,968,997 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on HAVCR2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1313140
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-03-31
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.