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Gene: RNF135 (ring finger protein 135) Homo sapiens
Symbol: RNF135
Name: ring finger protein 135
Description: Exhibits several functions, including RIG-I binding activity; identical protein binding activity; and ubiquitin protein ligase activity. Involved in several processes, including defense response to other organism; free ubiquitin chain polymerization; and protein K63-linked ubiquitination. Localizes to the cytoplasmic stress granule and ribonucleoprotein complex.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: E3 ubiquitin-protein ligase RNF135; L13; MGC13061; MMFD; REUL; RIG-I E3 ubiquitin ligase; RING-type E3 ubiquitin transferase RNF135; Riplet
Mus musculus (house mouse) : Rnf135 (ring finger protein 135)  MGI  Alliance
Rattus norvegicus (Norway rat) : Rnf135 (ring finger protein 135)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Rnf135 (ring finger protein 135)
Pan paniscus (bonobo/pygmy chimpanzee) : RNF135 (ring finger protein 135)
Canis lupus familiaris (dog) : RNF135 (ring finger protein 135)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rnf135 (ring finger protein 135)
Sus scrofa (pig) : RNF135 (ring finger protein 135)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381730,968,642 - 30,999,911 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371729,296,224 - 29,326,929 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361726,322,082 - 26,351,053 (+)NCBINCBI36hg18NCBI36
Celera1726,218,879 - 26,247,850 (+)NCBI
Cytogenetic Map17q11.2NCBI
HuRef1725,508,635 - 25,537,506 (+)NCBIHuRef
CHM1_11729,360,522 - 29,390,158 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on RNF135
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1313173
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.