Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: TOPORS (TOP1 binding arginine/serine rich protein) Homo sapiens
Analyze
Symbol: TOPORS
Name: TOP1 binding arginine/serine rich protein
Description: Exhibits several functions, including DNA topoisomerase binding activity; antigen binding activity; and ubiquitin-like protein transferase activity. Involved in several processes, including intrinsic apoptotic signaling pathway in response to DNA damage; positive regulation of ubiquitin-protein transferase activity; and protein modification by small protein conjugation. Localizes to several cellular components, including the microtubule cytoskeleton; nuclear body; and photoreceptor connecting cilium. Predicted to colocalize with the cytoplasmic dynein complex. Implicated in retinitis pigmentosa 31.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: E3 ubiquitin-protein ligase Topors; LUN; P53BP3; RING-type E3 ubiquitin transferase Topors; RP31; SUMO1-protein E3 ligase Topors; topoisomerase I binding protein; topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase; topoisomerase I-binding RING finger protein; TP53BPL; tumor suppressor p53-binding protein 3
Orthologs:
Mus musculus (house mouse) : Topors (topoisomerase I binding, arginine/serine-rich)  MGI  Alliance
Rattus norvegicus (Norway rat) : Topors (TOP1 binding arginine/serine rich protein)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Topors (TOP1 binding arginine/serine rich protein)
Pan paniscus (bonobo/pygmy chimpanzee) : TOPORS (TOP1 binding arginine/serine rich protein)
Canis lupus familiaris (dog) : TOPORS (TOP1 binding arginine/serine rich protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Topors (TOP1 binding arginine/serine rich protein)
Sus scrofa (pig) : TOPORS (TOP1 binding arginine/serine rich protein)
more info ...
Related Pseudogenes: TOPORSLP  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38932,540,544 - 32,552,628 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37932,540,542 - 32,552,626 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36932,530,542 - 32,542,601 (-)NCBINCBI36hg18NCBI36
Build 34932,530,542 - 32,542,601NCBI
Celera932,471,749 - 32,483,828 (-)NCBI
Cytogenetic Map9p21.1NCBI
HuRef932,496,996 - 32,509,408 (-)NCBIHuRef
CHM1_1932,540,543 - 32,552,661 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on TOPORS
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1313199
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.