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Gene: TOPORS (TOP1 binding arginine/serine rich protein) Homo sapiens
Symbol: TOPORS
Name: TOP1 binding arginine/serine rich protein
Description: Exhibits several functions, including DNA topoisomerase binding activity; antigen binding activity; and ubiquitin-like protein transferase activity. Involved in several processes, including intrinsic apoptotic signaling pathway in response to DNA damage; positive regulation of ubiquitin-protein transferase activity; and protein modification by small protein conjugation. Localizes to several cellular components, including the microtubule cytoskeleton; nuclear body; and photoreceptor connecting cilium. Predicted to colocalize with the cytoplasmic dynein complex. Implicated in retinitis pigmentosa 31.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: E3 ubiquitin-protein ligase Topors; LUN; P53BP3; RING-type E3 ubiquitin transferase Topors; RP31; SUMO1-protein E3 ligase Topors; topoisomerase I binding protein; topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase; topoisomerase I-binding RING finger protein; TP53BPL; tumor suppressor p53-binding protein 3
Mus musculus (house mouse) : Topors (topoisomerase I binding, arginine/serine-rich)  MGI  Alliance
Rattus norvegicus (Norway rat) : Topors (TOP1 binding arginine/serine rich protein)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Topors (TOP1 binding arginine/serine rich protein)
Pan paniscus (bonobo/pygmy chimpanzee) : TOPORS (TOP1 binding arginine/serine rich protein)
Canis lupus familiaris (dog) : TOPORS (TOP1 binding arginine/serine rich protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Topors (TOP1 binding arginine/serine rich protein)
Sus scrofa (pig) : TOPORS (TOP1 binding arginine/serine rich protein)
more info ...
Related Pseudogenes: TOPORSLP  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38932,540,544 - 32,552,628 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37932,540,542 - 32,552,626 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36932,530,542 - 32,542,601 (-)NCBINCBI36hg18NCBI36
Build 34932,530,542 - 32,542,601NCBI
Celera932,471,749 - 32,483,828 (-)NCBI
Cytogenetic Map9p21.1NCBI
HuRef932,496,996 - 32,509,408 (-)NCBIHuRef
CHM1_1932,540,543 - 32,552,661 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on TOPORS
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1313199
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.