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Gene: MAP4K4 (mitogen-activated protein kinase kinase kinase kinase 4) Homo sapiens
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Symbol: MAP4K4
Name: mitogen-activated protein kinase kinase kinase kinase 4
Description: Exhibits ATP binding activity; kinase activity; and microtubule binding activity. Involved in several processes, including negative regulation of apoptotic process; positive regulation of cell migration; and regulation of JNK cascade. Localizes to the cytoplasm and focal adhesion.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: epididymis secretory protein Li 31; FLH21957; FLJ10410; FLJ20373; FLJ90111; HEL-S-31; hepatocyte progenitor kinase-like/germinal center kinase-like kinase; HGK; HPK/GCK-like kinase HGK; KIAA0687; MAPK/ERK kinase kinase kinase 4; MEK kinase kinase 4; MEKKK 4; MEKKK4; nck-interacting kinase; NIK; Ste20 group protein kinase HGK
Orthologs:
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382101,697,703 - 101,894,690 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372102,314,165 - 102,511,152 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362101,680,920 - 101,877,584 (+)NCBINCBI36hg18NCBI36
Build 342101,773,005 - 101,969,669NCBI
Celera296,515,852 - 96,712,368 (+)NCBI
Cytogenetic Map2q11.2NCBI
HuRef296,077,883 - 96,275,019 (+)NCBIHuRef
CHM1_12102,318,538 - 102,515,492 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on MAP4K4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1313282
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.