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Gene: Alox12b (arachidonate 12-lipoxygenase, 12R type) Mus musculus
Symbol: Alox12b
Name: arachidonate 12-lipoxygenase, 12R type
Description: Exhibits arachidonate 12(S)-lipoxygenase activity; arachidonate 8(R)-lipoxygenase activity; and linoleate 9S-lipoxygenase activity. Involved in several processes, including ceramide biosynthetic process; establishment of skin barrier; and long-chain fatty acid metabolic process. Localizes to perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 2. Is expressed in cerebral cortex; gut epithelium; nasal cavity epithelium; and skin. Orthologous to human ALOX12B (arachidonate 12-lipoxygenase, 12R type).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 12R-lipoxygenase; 12R-LOX; Aloxe2; arachidonate 12-lipoxygenase, 12R-type; e-LOX 2; e-LOX2; epidermis-type lipoxygenase 12; epidermis-type lipoxygenase 2; MGC130560
Homo sapiens (human) : ALOX12B (arachidonate 12-lipoxygenase, 12R type)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Alox12b (arachidonate 12-lipoxygenase, 12R type)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Alox12b (arachidonate 12-lipoxygenase, 12R type)
Pan paniscus (bonobo/pygmy chimpanzee) : ALOX12B (arachidonate 12-lipoxygenase, 12R type)
Canis lupus familiaris (dog) : ALOX12B (arachidonate 12-lipoxygenase, 12R type)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Alox12b (arachidonate 12-lipoxygenase, 12R type)
Sus scrofa (pig) : ALOX12B (arachidonate 12-lipoxygenase, 12R type)
Chlorocebus sabaeus (African green monkey) : ALOX12B (arachidonate 12-lipoxygenase, 12R type)
Heterocephalus glaber (naked mole-rat) : Alox12b (arachidonate 12-lipoxygenase, 12R type)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1169,156,989 - 69,169,792 (+)EnsemblGRCm38mm10GRCm38
GRCm381169,157,072 - 69,169,791 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371168,970,574 - 68,983,293 (+)NCBIGRCm37mm9NCBIm37
MGSCv361168,973,267 - 68,985,986 (+)NCBImm8
Celera1176,102,080 - 76,118,886 (+)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1142.38NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Alox12b
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1313296
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.