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Gene: NKX3-1 (NK3 homeobox 1) Homo sapiens
Symbol: NKX3-1
Name: NK3 homeobox 1
Description: Exhibits several functions, including cysteine-type endopeptidase activator activity involved in apoptotic process; estrogen receptor binding activity; and histone deacetylase binding activity. Involved in several processes, including cellular response to cytokine stimulus; positive regulation of cell communication; and positive regulation of nitrogen compound metabolic process. Localizes to cytosol; nucleoplasm; and site of DNA damage. Implicated in hepatocellular carcinoma. Biomarker of hepatocellular carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: BAPX2; homeobox protein NK-3 homolog A; homeobox protein Nkx-3.1; NK homeobox, family 3, A; NK3 transcription factor homolog A; NK3 transcription factor related, locus 1; NKX3; NKX3.1; NKX3A
Mus musculus (house mouse) : Nkx3-1 (NK3 homeobox 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Nkx3-1 (NK3 homeobox 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nkx3-1 (NK3 homeobox 1)
Pan paniscus (bonobo/pygmy chimpanzee) : NKX3-1 (NK3 homeobox 1)
Canis lupus familiaris (dog) : NKX3-1 (NK3 homeobox 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nkx3-1 (NK3 homeobox 1)
Sus scrofa (pig) : NKX3-1 (NK3 homeobox 1)
Chlorocebus sabaeus (African green monkey) : NKX3-1 (NK3 homeobox 1)
Heterocephalus glaber (naked mole-rat) : Nkx3-1 (NK3 homeobox 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl823,678,697 - 23,682,938 (-)EnsemblGRCh38hg38GRCh38
GRCh38823,678,693 - 23,682,938 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37823,536,206 - 23,540,450 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36823,592,173 - 23,596,395 (-)NCBINCBI36hg18NCBI36
Build 34823,592,172 - 23,596,395NCBI
Celera822,499,634 - 22,503,878 (-)NCBI
Cytogenetic Map8p21.2NCBI
HuRef822,081,521 - 22,085,754 (-)NCBIHuRef
CHM1_1823,738,407 - 23,742,639 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on NKX3-1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1313354
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-09-08
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.