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Gene: IDH2 (isocitrate dehydrogenase (NADP(+)) 2) Homo sapiens
Symbol: IDH2
Name: isocitrate dehydrogenase (NADP(+)) 2
Description: Exhibits isocitrate dehydrogenase (NADP+) activity. Predicted to be involved in 2-oxoglutarate metabolic process; NADP metabolic process; and isocitrate metabolic process. Localizes to the mitochondrion. Implicated in D-2-hydroxyglutaric aciduria 2; acute myeloid leukemia; hepatocellular clear cell carcinoma; and intrahepatic cholangiocarcinoma. Biomarker of hepatocellular carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: D2HGA2; ICD-M; IDH; IDHM; IDP; IDPM; isocitrate dehydrogenase (NADP(+)) 2, mitochondrial; isocitrate dehydrogenase 2 (NADP+), mitochondrial; isocitrate dehydrogenase [NADP], mitochondrial; isocitrate dehydrogenase, mitochondrial; mNADP-IDH; NADP(+)-specific ICDH; NADP+-specific ICDH; oxalosuccinate decarboxylase
Mus musculus (house mouse) : Idh2 (isocitrate dehydrogenase 2 (NADP+), mitochondrial)  MGI  Alliance
Rattus norvegicus (Norway rat) : Idh2 (isocitrate dehydrogenase (NADP(+)) 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Idh2 (isocitrate dehydrogenase (NADP(+)) 2)
Pan paniscus (bonobo/pygmy chimpanzee) : IDH2 (isocitrate dehydrogenase (NADP(+)) 2)
Canis lupus familiaris (dog) : IDH2 (isocitrate dehydrogenase (NADP(+)) 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Idh2 (isocitrate dehydrogenase (NADP(+)) 2)
Sus scrofa (pig) : IDH2 (isocitrate dehydrogenase (NADP(+)) 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381590,083,045 - 90,102,554 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371590,626,283 - 90,645,730 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361588,428,214 - 88,446,712 (-)NCBINCBI36hg18NCBI36
Build 341588,428,217 - 88,446,712NCBI
Celera1567,031,136 - 67,049,657 (-)NCBI
Cytogenetic Map15q26.1NCBI
HuRef1566,738,326 - 66,745,989 (-)NCBIHuRef
CHM1_11590,468,783 - 90,487,361 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on IDH2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1313391
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-11-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.