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Gene: IDH2 (isocitrate dehydrogenase (NADP(+)) 2) Homo sapiens
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Symbol: IDH2
Name: isocitrate dehydrogenase (NADP(+)) 2
Description: Exhibits isocitrate dehydrogenase (NADP+) activity. Predicted to be involved in 2-oxoglutarate metabolic process; NADP metabolic process; and isocitrate metabolic process. Localizes to the mitochondrion. Implicated in D-2-hydroxyglutaric aciduria 2; acute myeloid leukemia; hepatocellular clear cell carcinoma; and intrahepatic cholangiocarcinoma. Biomarker of hepatocellular carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: D2HGA2; ICD-M; IDH; IDHM; IDP; IDPM; isocitrate dehydrogenase (NADP(+)) 2, mitochondrial; isocitrate dehydrogenase 2 (NADP+), mitochondrial; isocitrate dehydrogenase [NADP], mitochondrial; isocitrate dehydrogenase, mitochondrial; mNADP-IDH; NADP(+)-specific ICDH; NADP+-specific ICDH; oxalosuccinate decarboxylase
Orthologs:
Mus musculus (house mouse) : Idh2 (isocitrate dehydrogenase 2 (NADP+), mitochondrial)  MGI  Alliance
Rattus norvegicus (Norway rat) : Idh2 (isocitrate dehydrogenase (NADP(+)) 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Idh2 (isocitrate dehydrogenase (NADP(+)) 2)
Pan paniscus (bonobo/pygmy chimpanzee) : IDH2 (isocitrate dehydrogenase (NADP(+)) 2)
Canis lupus familiaris (dog) : IDH2 (isocitrate dehydrogenase (NADP(+)) 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Idh2 (isocitrate dehydrogenase (NADP(+)) 2)
Sus scrofa (pig) : IDH2 (isocitrate dehydrogenase (NADP(+)) 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381590,083,045 - 90,102,554 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371590,626,283 - 90,645,730 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361588,428,214 - 88,446,712 (-)NCBINCBI36hg18NCBI36
Build 341588,428,217 - 88,446,712NCBI
Celera1567,031,136 - 67,049,657 (-)NCBI
Cytogenetic Map15q26.1NCBI
HuRef1566,738,326 - 66,745,989 (-)NCBIHuRef
CHM1_11590,468,783 - 90,487,361 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on IDH2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1313391
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-11-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.