Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: KDM5A (lysine demethylase 5A) Homo sapiens
Analyze
Symbol: KDM5A
Name: lysine demethylase 5A
CRRD ID: 1313452
Description: Exhibits several functions, including histone demethylase activity (H3-K4 specific); methylated histone binding activity; and zinc ion binding activity. Involved in histone H3-K4 demethylation; positive regulation of transcription, DNA-templated; and regulation of DNA-binding transcription factor activity. Localizes to nucleus. Implicated in ankylosing spondylitis. Biomarker of alopecia areata; breast cancer; lung non-small cell carcinoma; prostate cancer; and stomach carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: [histone H3]-trimethyl-L-lysine(4) demethylase 5A; histone demethylase JARID1A; JARID1A; jumonji, AT rich interactive domain 1A; Jumonji, AT rich interactive domain 1A (RBP2-like); jumonji/ARID domain-containing protein 1A; lysine (K)-specific demethylase 5A; lysine-specific demethylase 5A; RBBP-2; RBBP2; RBP2; retinoblastoma binding protein 2; retinoblastoma-binding protein 2
Orthologs:
Mus musculus (house mouse) : Kdm5a (lysine (K)-specific demethylase 5A)  MGI  Alliance
Rattus norvegicus (Norway rat) : Kdm5a (lysine demethylase 5A)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Kdm5a (lysine demethylase 5A)
Pan paniscus (bonobo/pygmy chimpanzee) : KDM5A (lysine demethylase 5A)
Canis lupus familiaris (dog) : KDM5A (lysine demethylase 5A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Kdm5a (lysine demethylase 5A)
Sus scrofa (pig) : KDM5A (lysine demethylase 5A)
Chlorocebus sabaeus (African green monkey) : KDM5A (lysine demethylase 5A)
Heterocephalus glaber (naked mole-rat) : Kdm5a (lysine demethylase 5A)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: RBP2 (Gene ID: 5948) and KDM5A (Gene ID: 5927) share the RBP2 symbol/alias in common. RBP2 is a widely used alternative name for lysine demethylase 5A (KDM5A), which can be confused with the official symbol for retinol binding protein 2 (RBP2). [03 Jul 2018]
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl12280,057 - 389,320 (-)EnsemblGRCh38hg38GRCh38
GRCh3812280,057 - 389,320 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3712389,223 - 498,620 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612259,484 - 368,881 (-)NCBINCBI36hg18NCBI36
Build 3412263,762 - 368,673NCBI
Celera121,998,056 - 2,107,462 (-)NCBI
Cytogenetic Map12p13.33NCBI
HuRef12242,343 - 351,308 (-)NCBIHuRef
CHM1_112388,218 - 497,622 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on KDM5A
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1313452
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-10-06
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.