TRIM11 (tripartite motif containing 11) - Chinchilla Research Resource Database
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Gene: TRIM11 (tripartite motif containing 11) Homo sapiens
Analyze
Symbol: TRIM11
Name: tripartite motif containing 11
CRRD ID: 1313482
Description: Predicted to have ubiquitin protein ligase activity. Involved in innate immune response; negative regulation of viral process; and positive regulation of viral entry into host cell. Localizes to cytosol and nucleoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: BIA1; E3 ubiquitin-protein ligase TRIM11; RING finger protein 92; RING-type E3 ubiquitin transferase TRIM11; RNF92; tripartite motif-containing 11; tripartite motif-containing protein 11
Orthologs:
Mus musculus (house mouse) : Trim11 (tripartite motif-containing 11)  MGI  Alliance
Rattus norvegicus (Norway rat) : Trim11 (tripartite motif-containing 11)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Trim11 (tripartite motif containing 11)
Pan paniscus (bonobo/pygmy chimpanzee) : TRIM11 (tripartite motif containing 11)
Canis lupus familiaris (dog) : TRIM11 (tripartite motif containing 11)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Trim11 (tripartite motif containing 11)
Sus scrofa (pig) : TRIM11 (tripartite motif containing 11)
Chlorocebus sabaeus (African green monkey) : TRIM11 (tripartite motif containing 11)
Heterocephalus glaber (naked mole-rat) : Trim11 (tripartite motif containing 11)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1228,393,673 - 228,406,835 (-)EnsemblGRCh38hg38GRCh38
GRCh381228,393,672 - 228,406,835 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371228,581,373 - 228,594,584 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361226,648,000 - 226,661,140 (-)NCBINCBI36hg18NCBI36
Build 341224,888,113 - 224,901,252NCBI
Celera1201,771,344 - 201,784,479 (-)NCBI
Cytogenetic Map1q42.13NCBI
HuRef1199,095,985 - 199,109,126 (-)NCBIHuRef
CHM1_11229,853,700 - 229,866,840 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

Additional References at PubMed
PMID:11331580   PMID:12477932   PMID:12670303   PMID:14702039   PMID:15489334   PMID:16098226   PMID:16904669   PMID:18029348   PMID:18248090   PMID:18275850   PMID:19472918   PMID:21143188  
PMID:21873635   PMID:22307522   PMID:22493164   PMID:23178488   PMID:23675467   PMID:24981174   PMID:25105968   PMID:25260751   PMID:25271088   PMID:26186194   PMID:26760575   PMID:27173435  
PMID:27329103   PMID:27432908   PMID:27498865   PMID:27737691   PMID:27880917   PMID:27888625   PMID:28065743   PMID:28244856   PMID:28514442   PMID:29190611   PMID:29240581   PMID:29581427  
PMID:29872149   PMID:30066433   PMID:30563406   PMID:30608062   PMID:30816511   PMID:31586073   PMID:31719797   PMID:31786079   PMID:31950060  


Genomics

Comparative Map Data
TRIM11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1228,393,673 - 228,406,835 (-)EnsemblGRCh38hg38GRCh38
GRCh381228,393,672 - 228,406,835 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371228,581,373 - 228,594,584 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361226,648,000 - 226,661,140 (-)NCBINCBI36hg18NCBI36
Build 341224,888,113 - 224,901,252NCBI
Celera1201,771,344 - 201,784,479 (-)NCBI
Cytogenetic Map1q42.13NCBI
HuRef1199,095,985 - 199,109,126 (-)NCBIHuRef
CHM1_11229,853,700 - 229,866,840 (-)NCBICHM1_1
Trim11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391158,865,054 - 58,882,288 (+)NCBI
GRCm381158,973,726 - 58,991,462 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1158,978,093 - 58,991,458 (+)EnsemblGRCm38mm10GRCm38
MGSCv371158,791,618 - 58,804,960 (+)NCBIGRCm37mm9NCBIm37
MGSCv361158,794,311 - 58,807,653 (+)NCBImm8
Celera1163,744,428 - 63,757,877 (+)NCBICelera
Cytogenetic Map11B1.3NCBI
Trim11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01045,322,199 - 45,335,030 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1045,322,248 - 45,335,030 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01045,078,796 - 45,091,446 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41045,270,583 - 45,283,954 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11045,284,255 - 45,294,925 (+)NCBI
Celera1043,024,655 - 43,037,489 (+)NCBICelera
Cytogenetic Map10q22NCBI
Trim11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955581114,750 - 125,143 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955581114,750 - 123,410 (+)NCBIChiLan1.0ChiLan1.0
TRIM11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11209,006,979 - 209,019,994 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1209,006,979 - 209,019,994 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01203,795,924 - 203,809,703 (-)NCBIMhudiblu_PPA_v0panPan3
TRIM11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.114640,375 - 647,427 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Trim11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493713511,350 - 21,235 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TRIM11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl251,733,180 - 51,743,256 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1251,729,333 - 51,743,256 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TRIM11
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl251,323,528 - 1,335,504 (+)Ensembl
ChlSab1.1251,322,817 - 1,336,535 (+)NCBI
Trim11
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249371,100,297 - 1,109,017 (-)NCBI

Position Markers
A009J23  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371228,581,436 - 228,581,545UniSTSGRCh37
Build 361226,648,059 - 226,648,168RGDNCBI36
Celera1201,771,403 - 201,771,512RGD
Cytogenetic Map1q42.13UniSTS
HuRef1199,096,044 - 199,096,153UniSTS
GeneMap99-GB4 RH Map1720.07UniSTS
NCBI RH Map12074.2UniSTS
TRIM17_3821  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371228,595,721 - 228,596,418UniSTSGRCh37
Build 361226,662,344 - 226,663,041RGDNCBI36
Celera1201,785,677 - 201,786,374RGD
HuRef1199,110,316 - 199,111,013UniSTS
G32582  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371228,581,436 - 228,581,545UniSTSGRCh37
Celera1201,771,403 - 201,771,512UniSTS
Cytogenetic Map1q42.13UniSTS
HuRef1199,096,044 - 199,096,153UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:3043
Count of miRNA genes:995
Interacting mature miRNAs:1223
Transcripts:ENST00000284551, ENST00000366699, ENST00000460651, ENST00000475775, ENST00000493030, ENST00000602308, ENST00000602582
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 205 80 126 73 760 47 325 48 724 72 618 343 37 7 84 2 2
Low 2234 2905 1600 551 1190 418 3998 2107 3005 347 842 1270 138 1 1197 2670 4
Below cutoff 6 1 34 42 5 34

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000284551   ⟹   ENSP00000284551
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1228,393,676 - 228,406,835 (-)Ensembl
RefSeq Acc Id: ENST00000366699   ⟹   ENSP00000355660
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1228,395,534 - 228,406,800 (-)Ensembl
RefSeq Acc Id: ENST00000475775
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1228,395,208 - 228,397,689 (-)Ensembl
RefSeq Acc Id: ENST00000493030   ⟹   ENSP00000473360
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1228,393,673 - 228,405,904 (-)Ensembl
RefSeq Acc Id: ENST00000602308   ⟹   ENSP00000473579
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1228,396,613 - 228,406,186 (-)Ensembl
RefSeq Acc Id: ENST00000602582   ⟹   ENSP00000473574
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1228,394,825 - 228,406,187 (-)Ensembl
RefSeq Acc Id: NM_145214   ⟹   NP_660215
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381228,393,676 - 228,406,835 (-)NCBI
GRCh371228,581,373 - 228,594,584 (-)NCBI
Build 361226,648,000 - 226,661,140 (-)NCBI Archive
Celera1201,771,344 - 201,784,479 (-)RGD
HuRef1199,095,985 - 199,109,126 (-)RGD
CHM1_11229,853,700 - 229,866,840 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011544285   ⟹   XP_011542587
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381228,393,672 - 228,406,644 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017002412   ⟹   XP_016857901
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381228,393,672 - 228,406,644 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_660215   ⟸   NM_145214
- UniProtKB: Q96F44 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011542587   ⟸   XM_011544285
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_016857901   ⟸   XM_017002412
- Peptide Label: isoform X1
- UniProtKB: Q96F44 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000473360   ⟸   ENST00000493030
RefSeq Acc Id: ENSP00000284551   ⟸   ENST00000284551
RefSeq Acc Id: ENSP00000355660   ⟸   ENST00000366699
RefSeq Acc Id: ENSP00000473574   ⟸   ENST00000602582
RefSeq Acc Id: ENSP00000473579   ⟸   ENST00000602308
Protein Domains
B30.2/SPRY

Promoters
RGD ID:6787066
Promoter ID:HG_KWN:7704
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   K562,   Lymphoblastoid
Transcripts:OTTHUMT00000099232
Position:
Human AssemblyChrPosition (strand)Source
Build 361226,651,496 - 226,652,512 (-)MPROMDB
RGD ID:6787067
Promoter ID:HG_KWN:7705
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3,   K562,   Lymphoblastoid
Transcripts:OTTHUMT00000096436
Position:
Human AssemblyChrPosition (strand)Source
Build 361226,656,286 - 226,657,332 (-)MPROMDB
RGD ID:6787072
Promoter ID:HG_KWN:7706
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:OTTHUMT00000095995,   OTTHUMT00000096435,   UC001HST.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361226,660,586 - 226,661,607 (-)MPROMDB
RGD ID:6859196
Promoter ID:EPDNEW_H2763
Type:initiation region
Name:TRIM11_1
Description:tripartite motif containing 11
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381228,406,835 - 228,406,895EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 1q32.3-44(chr1:214023812-248918469)x3 copy number gain See cases [RCV000050981] Chr1:214023812..248918469 [GRCh38]
Chr1:214197155..249212668 [GRCh37]
Chr1:212263778..247179291 [NCBI36]
Chr1:1q32.3-44
pathogenic
GRCh38/hg38 1q41-44(chr1:223347693-248918469)x3 copy number gain See cases [RCV000050581] Chr1:223347693..248918469 [GRCh38]
Chr1:223521035..249212668 [GRCh37]
Chr1:221587658..247179291 [NCBI36]
Chr1:1q41-44
pathogenic
GRCh38/hg38 1q41-44(chr1:221902539-248918469)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051875]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051875]|See cases [RCV000051875] Chr1:221902539..248918469 [GRCh38]
Chr1:222075881..249212668 [GRCh37]
Chr1:220142504..247179291 [NCBI36]
Chr1:1q41-44
pathogenic
GRCh38/hg38 1q41-44(chr1:223828500-248891309)x3 copy number gain See cases [RCV000051878] Chr1:223828500..248891309 [GRCh38]
Chr1:224016202..249185508 [GRCh37]
Chr1:222082825..247152131 [NCBI36]
Chr1:1q41-44
pathogenic
GRCh38/hg38 1q41-44(chr1:223887780-248891309)x3 copy number gain See cases [RCV000051880] Chr1:223887780..248891309 [GRCh38]
Chr1:224075482..249185508 [GRCh37]
Chr1:222142105..247152131 [NCBI36]
Chr1:1q41-44
pathogenic
GRCh38/hg38 1q42.11-44(chr1:224096488-248918469)x3 copy number gain See cases [RCV000051882] Chr1:224096488..248918469 [GRCh38]
Chr1:224284190..249212668 [GRCh37]
Chr1:222350813..247179291 [NCBI36]
Chr1:1q42.11-44
pathogenic
GRCh38/hg38 1q32.2-44(chr1:209646207-248931113)x3 copy number gain See cases [RCV000051861] Chr1:209646207..248931113 [GRCh38]
Chr1:209819552..249225312 [GRCh37]
Chr1:207886175..247191935 [NCBI36]
Chr1:1q32.2-44
pathogenic
GRCh38/hg38 1q41-42.13(chr1:221519280-228862141)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053955]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053955]|See cases [RCV000053955] Chr1:221519280..228862141 [GRCh38]
Chr1:221692622..228997888 [GRCh37]
Chr1:219759245..227064511 [NCBI36]
Chr1:1q41-42.13
pathogenic
NM_145214.2(TRIM11):c.77C>T (p.Pro26Leu) single nucleotide variant Malignant melanoma [RCV000064563] Chr1:228406485 [GRCh38]
Chr1:228594186 [GRCh37]
Chr1:226660809 [NCBI36]
Chr1:1q42.13
not provided
GRCh38/hg38 1q32.2-44(chr1:209963625-248918469)x3 copy number gain See cases [RCV000134979] Chr1:209963625..248918469 [GRCh38]
Chr1:210136970..249212668 [GRCh37]
Chr1:208203593..247179291 [NCBI36]
Chr1:1q32.2-44
pathogenic
GRCh38/hg38 1q42.13(chr1:227613596-229249335)x4 copy number gain See cases [RCV000134940] Chr1:227613596..229249335 [GRCh38]
Chr1:227801297..229385082 [GRCh37]
Chr1:225867920..227451705 [NCBI36]
Chr1:1q42.13
likely pathogenic|uncertain significance
GRCh38/hg38 1q41-44(chr1:223815147-248918469)x3 copy number gain See cases [RCV000135839] Chr1:223815147..248918469 [GRCh38]
Chr1:224002849..249212668 [GRCh37]
Chr1:222069472..247179291 [NCBI36]
Chr1:1q41-44
pathogenic
GRCh38/hg38 1q42.12-42.2(chr1:226185124-232872488)x1 copy number loss See cases [RCV000135796] Chr1:226185124..232872488 [GRCh38]
Chr1:226372825..233008234 [GRCh37]
Chr1:224439448..231074857 [NCBI36]
Chr1:1q42.12-42.2
pathogenic
GRCh38/hg38 1q41-42.13(chr1:223347693-228556332)x1 copy number loss See cases [RCV000136636] Chr1:223347693..228556332 [GRCh38]
Chr1:223521035..228744033 [GRCh37]
Chr1:221587658..226810656 [NCBI36]
Chr1:1q41-42.13
pathogenic
GRCh38/hg38 1q42.11-44(chr1:224022862-248918469)x3 copy number gain See cases [RCV000137769] Chr1:224022862..248918469 [GRCh38]
Chr1:224210564..249212668 [GRCh37]
Chr1:222277187..247179291 [NCBI36]
Chr1:1q42.11-44
pathogenic
GRCh38/hg38 1q42.12-44(chr1:225438480-248787200)x3 copy number gain See cases [RCV000142448] Chr1:225438480..248787200 [GRCh38]
Chr1:225626182..249060210 [GRCh37]
Chr1:223692805..247048022 [NCBI36]
Chr1:1q42.12-44
pathogenic
GRCh38/hg38 1q42.12-42.13(chr1:225382172-230418801)x1 copy number loss See cases [RCV000143223] Chr1:225382172..230418801 [GRCh38]
Chr1:225569874..230554547 [GRCh37]
Chr1:223636497..228621170 [NCBI36]
Chr1:1q42.12-42.13
pathogenic
GRCh38/hg38 1q32.2-44(chr1:207346642-248930485)x3 copy number gain See cases [RCV000143727] Chr1:207346642..248930485 [GRCh38]
Chr1:207519987..249224684 [GRCh37]
Chr1:205586610..247191307 [NCBI36]
Chr1:1q32.2-44
pathogenic
GRCh37/hg19 1q31.3-42.13(chr1:197811907-228997888)x3 copy number gain See cases [RCV000240137] Chr1:197811907..228997888 [GRCh37]
Chr1:1q31.3-42.13
pathogenic
GRCh37/hg19 1q42.12-42.13(chr1:226871745-229906954)x1 copy number loss See cases [RCV000240001] Chr1:226871745..229906954 [GRCh37]
Chr1:1q42.12-42.13
uncertain significance
GRCh37/hg19 1q31.3-44(chr1:195483439-249213000)x3 copy number gain See cases [RCV000449172] Chr1:195483439..249213000 [GRCh37]
Chr1:1q31.3-44
pathogenic
GRCh37/hg19 1q41-44(chr1:214697099-249224684)x3 copy number gain See cases [RCV000449210] Chr1:214697099..249224684 [GRCh37]
Chr1:1q41-44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1q42.11-44(chr1:224105294-249224684)x3 copy number gain See cases [RCV000510981] Chr1:224105294..249224684 [GRCh37]
Chr1:1q42.11-44
pathogenic
GRCh37/hg19 1q41-44(chr1:218252551-249224684)x3 copy number gain not provided [RCV000684700] Chr1:218252551..249224684 [GRCh37]
Chr1:1q41-44
pathogenic
GRCh37/hg19 1q42.13(chr1:227696109-229152386)x3 copy number gain not provided [RCV000684706] Chr1:227696109..229152386 [GRCh37]
Chr1:1q42.13
likely pathogenic
GRCh37/hg19 1q42.13-44(chr1:228529973-249181598)x3 copy number gain not provided [RCV000684707] Chr1:228529973..249181598 [GRCh37]
Chr1:1q42.13-44
pathogenic
GRCh37/hg19 1q42.13(chr1:228408651-229301909)x4 copy number gain not provided [RCV000845650] Chr1:228408651..229301909 [GRCh37]
Chr1:1q42.13
uncertain significance
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1q42.13(chr1:228260287-228617063)x1 copy number loss not provided [RCV000736887] Chr1:228260287..228617063 [GRCh37]
Chr1:1q42.13
benign
GRCh37/hg19 1q42.13(chr1:228535364-228741147)x3 copy number gain not provided [RCV000736892] Chr1:228535364..228741147 [GRCh37]
Chr1:1q42.13
benign
GRCh37/hg19 1q41-42.2(chr1:223653722-234591807)x1 copy number loss not provided [RCV001005180] Chr1:223653722..234591807 [GRCh37]
Chr1:1q41-42.2
pathogenic
NM_145214.3(TRIM11):c.409-4G>T single nucleotide variant not provided [RCV000903397] Chr1:228402165 [GRCh38]
Chr1:228589866 [GRCh37]
Chr1:1q42.13
benign
NM_145214.3(TRIM11):c.1119G>A (p.Ala373=) single nucleotide variant not provided [RCV000883628] Chr1:228394993 [GRCh38]
Chr1:228582694 [GRCh37]
Chr1:1q42.13
benign
GRCh37/hg19 1q42.13(chr1:228297613-228703236) copy number gain Aortic valve disorder [RCV000770940] Chr1:228297613..228703236 [GRCh37]
Chr1:1q42.13
uncertain significance
GRCh37/hg19 1q42.13(chr1:228235107-228983659)x3 copy number gain not provided [RCV000848102] Chr1:228235107..228983659 [GRCh37]
Chr1:1q42.13
uncertain significance
GRCh37/hg19 1q42.13(chr1:228459781-228849579)x3 copy number gain not provided [RCV001005186] Chr1:228459781..228849579 [GRCh37]
Chr1:1q42.13
likely benign
GRCh37/hg19 1q25.3-44(chr1:182388773-249111240)x3 copy number gain not provided [RCV000845852] Chr1:182388773..249111240 [GRCh37]
Chr1:1q25.3-44
pathogenic
GRCh37/hg19 1q41-43(chr1:219916966-239004378)x3 copy number gain not provided [RCV001005175] Chr1:219916966..239004378 [GRCh37]
Chr1:1q41-43
pathogenic
GRCh37/hg19 1q32.2-44(chr1:210152794-249218992)x3 copy number gain See cases [RCV001194578] Chr1:210152794..249218992 [GRCh37]
Chr1:1q32.2-44
pathogenic
GRCh37/hg19 1q32.1-44(chr1:204045948-249218992)x3 copy number gain See cases [RCV001007407] Chr1:204045948..249218992 [GRCh37]
Chr1:1q32.1-44
pathogenic
GRCh37/hg19 1q42.13(chr1:228456544-228716927)x3 copy number gain not provided [RCV001259113] Chr1:228456544..228716927 [GRCh37]
Chr1:1q42.13
likely benign

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:16281 AgrOrtholog
COSMIC TRIM11 COSMIC
Ensembl Genes ENSG00000154370 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000284551 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000355660 UniProtKB/Swiss-Prot
  ENSP00000473360 UniProtKB/TrEMBL
  ENSP00000473574 UniProtKB/TrEMBL
  ENSP00000473579 UniProtKB/TrEMBL
Ensembl Transcript ENST00000284551 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000366699 UniProtKB/Swiss-Prot
  ENST00000493030 UniProtKB/TrEMBL
  ENST00000602308 UniProtKB/TrEMBL
  ENST00000602582 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.920 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/Swiss-Prot
GTEx ENSG00000154370 GTEx
HGNC ID HGNC:16281 ENTREZGENE
Human Proteome Map TRIM11 Human Proteome Map
InterPro B30.2/SPRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  B30.2/SPRY_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Butyrophylin_SPRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ConA-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPRY_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_B-box UniProtKB/Swiss-Prot
  Znf_RING UniProtKB/Swiss-Prot
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot
  Znf_RING_CS UniProtKB/Swiss-Prot
KEGG Report hsa:81559 UniProtKB/Swiss-Prot
NCBI Gene 81559 ENTREZGENE
OMIM 607868 OMIM
Pfam PRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-B_box UniProtKB/Swiss-Prot
PharmGKB PA38112 PharmGKB
PRINTS BUTYPHLNCDUF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE B302_SPRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_BBOX UniProtKB/Swiss-Prot
  ZF_RING_1 UniProtKB/Swiss-Prot
  ZF_RING_2 UniProtKB/Swiss-Prot
SMART BBOX UniProtKB/Swiss-Prot
  PRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RING UniProtKB/Swiss-Prot
  SPRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49899 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Hs.13543 ENTREZGENE
UniProt Q96F44 ENTREZGENE
  R4GMV1_HUMAN UniProtKB/TrEMBL
  R4GNB9_HUMAN UniProtKB/TrEMBL
  R4GNC3_HUMAN UniProtKB/TrEMBL
  TRI11_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary A6NKE2 UniProtKB/Swiss-Prot
  B2RB82 UniProtKB/Swiss-Prot
  B3KUS3 UniProtKB/Swiss-Prot
  B4DX88 UniProtKB/Swiss-Prot
  Q5VSU1 UniProtKB/Swiss-Prot
  Q8NCA6 UniProtKB/Swiss-Prot
  Q9C022 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-27 TRIM11  tripartite motif containing 11  TRIM11  tripartite motif-containing 11  Symbol and/or name change 5135510 APPROVED