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Gene: GPT2 (glutamic--pyruvic transaminase 2) Homo sapiens
Symbol: GPT2
Name: glutamic--pyruvic transaminase 2
Description: Exhibits L-alanine:2-oxoglutarate aminotransferase activity. Involved in 2-oxoglutarate metabolic process and L-alanine metabolic process. Predicted to localize to the mitochondrial matrix. Implicated in autosomal recessive non-syndromic intellectual disability. Biomarker of liver cancer and non-alcoholic fatty liver disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: alanine aminotransferase 2; ALT2; glutamate pyruvate transaminase 2; glutamic pyruvate transaminase (alanine aminotransferase) 2; glutamic pyruvate transaminase 2; glutamic--alanine transaminase 2; glutamic-pyruvate transaminase 2; GPT 2; MRT49
Mus musculus (house mouse) : Gpt2 (glutamic pyruvate transaminase (alanine aminotransferase) 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Gpt2 (glutamic--pyruvic transaminase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gpt2 (glutamic--pyruvic transaminase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : GPT2 (glutamic--pyruvic transaminase 2)
Canis lupus familiaris (dog) : GPT2 (glutamic--pyruvic transaminase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gpt2 (glutamic--pyruvic transaminase 2)
Sus scrofa (pig) : GPT2 (glutamic--pyruvic transaminase 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381646,884,362 - 46,931,289 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371646,918,308 - 46,965,201 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361645,475,809 - 45,522,699 (+)NCBINCBI36hg18NCBI36
Build 341645,475,808 - 45,522,699NCBI
Celera1631,426,465 - 31,473,333 (+)NCBI
Cytogenetic Map16q11.2NCBI
HuRef1632,808,713 - 32,855,581 (+)NCBIHuRef
CHM1_11648,325,386 - 48,372,277 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on GPT2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1313502
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.