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Gene: MKI67 (marker of proliferation Ki-67) Homo sapiens
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Symbol: MKI67
Name: marker of proliferation Ki-67
Description: Exhibits protein C-terminus binding activity. Involved in regulation of chromosome segregation and regulation of mitotic nuclear division. Localizes to nuclear body and nucleolus. Colocalizes with condensed chromosome. Implicated in Crohn's disease; breast cancer; human immunodeficiency virus infectious disease; and pancreatic cancer. Biomarker of several diseases, including Barrett's esophagus; diffuse large B-cell lymphoma; endocrine gland cancer (multiple); interstitial cystitis; and systemic lupus erythematosus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: antigen identified by monoclonal antibody Ki-67; antigen KI-67; antigen Ki67; KIA; MIB-; MIB-1; PPP1R105; proliferation marker protein Ki-67; proliferation-related Ki-67 antigen
Orthologs:
Mus musculus (house mouse) : Mki67 (antigen identified by monoclonal antibody Ki 67)  MGI  Alliance
Rattus norvegicus (Norway rat) : Mki67 (marker of proliferation Ki-67)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mki67 (marker of proliferation Ki-67)
Pan paniscus (bonobo/pygmy chimpanzee) : MKI67 (marker of proliferation Ki-67)
Canis lupus familiaris (dog) : MKI67 (marker of proliferation Ki-67)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mki67 (marker of proliferation Ki-67)
Sus scrofa (pig) : MKI67 (marker of proliferation Ki-67)
Chlorocebus sabaeus (African green monkey) : MKI67 (marker of proliferation Ki-67)
Heterocephalus glaber (naked mole-rat) : Mki67 (marker of proliferation Ki-67)
more info ...
Related Pseudogenes: MKI67P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl10128,096,659 - 128,126,423 (-)EnsemblGRCh38hg38GRCh38
GRCh3810128,096,659 - 128,126,423 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3710129,894,923 - 129,924,468 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3610129,784,913 - 129,814,645 (-)NCBINCBI36hg18NCBI36
Build 3410129,784,912 - 129,814,458NCBI
Celera10123,566,399 - 123,595,953 (-)NCBI
Cytogenetic Map10q26.2NCBI
HuRef10123,469,633 - 123,499,187 (-)NCBIHuRef
CHM1_110130,177,330 - 130,206,878 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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Disease Annotations
Gene-Chemical Interaction Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on MKI67
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1313525
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-06-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.